TY - JOUR AB - α‑taxilin is a binding partner of syntaxins, which are the central coordinators of membrane traffic. Expression of α‑taxilin has been implicated in the development of human glioblastoma, hepatocellular carcinoma and renal cell carcinoma. In the present study, the clinical significance of α‑taxilin expression in colorectal cancer (CRC) was investigated. A total of 20 cases of colorectal intramucosal adenocarcinoma (IMA) with adenoma were analyzed using immunohistochemical analysis. The results demonstrated that α‑taxilin expression was significantly associated with Ki‑67 indices in adenoma and IMA. The patients expressed equally high levels of α‑taxilin in the upper third of the intramucosal glands. These results suggest that α‑taxilin expression is significantly associated with the proliferative activity of CRC, but that its overexpression alone is not a biomarker of malignancy. Next, α‑taxilin expression was investigated in 57 advanced CRCs and its association with prognosis was determined. Well‑differentiated and/or moderately differentiated adenocarcinomas in the left‑sided colon with anatomic stage II and/or III were analyzed. α‑taxilin expression levels were high on the surface of nearly all tumors, but variable at the deep advancing edge. α‑taxilin levels at the advancing edge were not significantly associated with local invasiveness or prognosis. In conclusion, α‑taxilin is a cell proliferation marker in colorectal epithelial neoplasms but cannot be a marker of malignancy or prognosis of CRCs. AD - Department of Gastroenterology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321‑0293, Japan Department of Diagnostic Pathology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321‑0293, Japan Department of Surgical Oncology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321‑0293, Japan Department of Gastroenterological Surgery, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321‑0293, Japan Department of Molecular and Cell Biology, School of Medicine, Dokkyo Medical University, Mibu, Tochigi 321‑0293, Japan AU - Kanamori,Akira AU - Imai,Yasuo AU - Ihara,Keisuke AU - Nagata,Hitoshi AU - Nakano,Masakazu AU - Tominaga,Keiichi AU - Shimizu,Hiroaki AU - Makiyama,Tomihiko AU - Kuroda,Hajime AU - Shirataki,Hiromichi AU - Hiraishi,Hideyuki DA - 2017/08/01 DO - 10.3892/ol.2017.6309 EP - 1476 IS - 2 JO - Oncol Lett KW - α‑taxilin colorectal cancer proliferation Ki‑67 prognosis PY - 2017 SN - 1792-1074 1792-1082 SP - 1471 ST - α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer T2 - Oncology Letters TI - α‑taxilin overexpression correlates with proliferation activity but not with prognosis of colorectal cancer UR - https://doi.org/10.3892/ol.2017.6309 VL - 14 ER -