TY - JOUR AB - The role of c-Jun N-terminal kinases (JNKs) in the pathogenesis of cancer is well‑known due to their involvement in carcinogenesis. Although previous studies have discussed different functions of JNKs depending on cell type, the present study aimed to investigate the function of JNKs in nasopharyngeal carcinoma (NPC) cells, as well as their involvement in chemotherapy sensitivity to Adriamycin. The present results showed that Adriamycin administration reduced cell viability and led to elevated expressions of c‑Jun, phosphorylated JNK and phosphorylated c‑Jun, indicating an activated JNK pathway. Notably, JNK inhibition by SP600125 also reduced cell growth. Thus, Adriamycin treatment combined with SP600125 was more effective on cell growth inhibition than each agent alone. The apoptosis analysis confirmed the reduction in cell growth. Therefore, these data provide evidence that the JNK pathway activity is negatively associated with cell viability, and its decline could sensitize NPC cells to Adriamycin. AD - Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China AU - Liu,Yong AU - Feng,Jing AU - Zhao,Ming AU - Wu,Jingbo AU - Fan,Juan AU - Wen,Qinglian AU - Xu,Jinhui AU - Zhang,Jianwen AU - Fu,Shaozhi AU - Wang,Biqiong AU - Lu,Yun AU - Xiong,Kang AU - Xiang,Li AU - Zhang,Yanling AU - Yang,Linglin DA - 2017/08/01 DO - 10.3892/ol.2017.6349 EP - 1794 IS - 2 JO - Oncol Lett KW - c‑Jun N‑terminal kinase pathway chemotherapeutic sensitivity nasopharyngeal carcinoma apoptosis PY - 2017 SN - 1792-1074 1792-1082 SP - 1790 ST - JNK pathway inhibition enhances chemotherapeutic sensitivity to Adriamycin in nasopharyngeal carcinoma cells T2 - Oncology Letters TI - JNK pathway inhibition enhances chemotherapeutic sensitivity to Adriamycin in nasopharyngeal carcinoma cells UR - https://doi.org/10.3892/ol.2017.6349 VL - 14 ER -