TY - JOUR AB - The present study explored the effect of telomerase reverse transcriptase (TERT) on the growth and apoptosis of fibrosarcoma, and investigated the potential molecular signalling pathways underlying its effect. A plasmid was constructed in order to overexpress TERT and siRNA was used to knockdown TERT. The effect of TERT on fibrosarcoma cells in vitro was studied by performing reverse transcription‑quantitative PCR and western blotting to determine the expression of p53, survivin, caspase‑3, caspase‑7 and PKB. Knockdown of TERT suppressed cell growth, decreased fibrosarcoma volume, decreased survivin and PKB expression, and increased caspase‑3 expression. The results of the present study suggest that TERT regulates the growth of fibrosarcoma in vitro and in vivo, and that this is associated with the expression of caspase‑3 and survivin, in addition to the PKB signalling pathway. AD - Department of Orthopedics, Chinese Medicine Hospital of Jiulongpo, Chongqing 400080, P.R. China Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Helongjiang 150001, P.R. China Department of Orthopedics, Nanning Second People's Hospital, Nanning, Guangxi 530031, P.R. China AU - Ma,Qiuye AU - Yu,Yidong AU - Dai,Linlin AU - Qu,Xuehua AU - Cong,Shan AU - Liang,Hongsuo DA - 2017/08/01 DO - 10.3892/ol.2017.6373 EP - 1942 IS - 2 JO - Oncol Lett KW - telomerase reverse transcriptase fibrosarcoma RNA interference apoptosis PY - 2017 SN - 1792-1074 1792-1082 SP - 1939 ST - Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB T2 - Oncology Letters TI - Effect of TERT on the growth of fibrosarcoma via caspase-3, survivin and PKB UR - https://doi.org/10.3892/ol.2017.6373 VL - 14 ER -