TY - JOUR AB - As an oncogene, MACC1 serves an important function in cancer progression and metastasis. However, the effect of MACC1 in esophageal carcinoma (EC) remains to be fully understood. The present study assessed the association between MACC1 expression and the progression of EC cells. A small interfering (si)RNA was delivered into EC cells to downregulate MACC1 expression. The MTT assay demonstrated that EC cell viability was reduced by siRNA‑MACC1. Decreasing MACC1 expression increased the apoptotic rate of EC cells compared with control cells. Transwell and Matrigel assays demonstrated that EC cell migration and invasion, respectively, were downregulated by siRNA‑MACC1. Furthermore, knocking down MACC1 suppressed the phosphoinositide 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway by upregulating the expression of phosphatase and tensin homolog (PTEN), a tumor suppressor. The results of the present study revealed that MACC1 expression affected cellular functions of the EC cells through the PTEN/PI3K/Akt signaling pathway. Therefore, MACC1 may potentially serve as a novel biomarker and therapeutic target for EC. AD - Department of General Surgery, Wujiang No. 1 People's Hospital, Suzhou, Jiangsu 215200, P.R. China Department of Gynaecology and Obstetrics, Health Center of Songling, Suzhou, Jiangsu 215200, P.R. China AU - Qian,Li‑Qiang AU - Li,Xia‑Qin AU - Ye,Peng‑Hui AU - Su,Hao‑Yuan AU - Wang,Gang AU - Liu,Yan AU - Shen,Gen‑Hai AU - Gao,Quan‑Gen DA - 2017/10/01 DO - 10.3892/ol.2017.6790 EP - 4905 IS - 4 JO - Oncol Lett KW - esophageal carcinoma MACC1 phosphatase and tensin homolog phosphoinositide 3‑kinase protein kinase B PY - 2017 SN - 1792-1074 1792-1082 SP - 4897 ST - Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway T2 - Oncology Letters TI - Downregulation of MACC1 inhibits the viability, invasion and migration and induces apoptosis in esophageal carcinoma cells through the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway UR - https://doi.org/10.3892/ol.2017.6790 VL - 14 ER -