TY - JOUR AB - Lung cancer is one of the most common types of tumors and the leading cause of cancer‑associated mortality in the world. Additionally, non‑small cell lung cancer (NSCLC) accounts for ~80% of all lung cancer cases. Epithelial‑ mesenchymal transition (EMT) is an important cell biological process, which is associated with cancer migration, metastasis, asthma and fibrosis in the lung. In the present study, it was revealed that miR‑145‑5p was able to suppress EMT by inactivating the c‑Jun N‑terminal kinase (JNK) signaling pathway in NSCLC cells. Mitogen‑activated protein kinase kinase kinase 1 (MAP3K1) was predicted and confirmed to be a novel target of miR‑145‑5p. Overexpression of MAP3K1 was able to reverse the inhibition of EMT induced by miR‑145‑5p via the JNK signaling pathway. Overall, the results revealed that miR‑145‑5p inhibits EMT via the JNK signaling pathway by targeting MAP3K1 in NSCLC cells. AD - Department of Respiratory Medicine, Guangdong No. 2 Provincial People Hospital, Guangzhou, Guangdong 510317, P.R. China Department of Cardiothoracic Surgery, Guangdong No. 2 Provincial People Hospital, Guangzhou, Guangdong 510317, P.R. China AU - Chang,Yongmei AU - Yan,Wensen AU - Sun,Cong AU - Liu,Qingfeng AU - Wang,Jun AU - Wang,Mingzhi DA - 2017/12/01 DO - 10.3892/ol.2017.7092 EP - 6928 IS - 6 JO - Oncol Lett KW - miR‑145‑5p epithelial‑mesenchymal transition mitogen‑ activated protein kinase kinase kinase 1 Jun N‑terminal kinase 2 non‑small cell lung cancer PY - 2017 SN - 1792-1074 1792-1082 SP - 6923 ST - miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells T2 - Oncology Letters TI - miR‑145‑5p inhibits epithelial‑mesenchymal transition via the JNK signaling pathway by targeting MAP3K1 in non‑small cell lung cancer cells UR - https://doi.org/10.3892/ol.2017.7092 VL - 14 ER -