TY - JOUR AB - A novel, minimally invasive interventional technique, radiofrequency heat (RFH), has been suggested to improve the efficacy of chemotherapy for solid organ tumors. However, the treatment for prostate cancer has not been completely characterized. The aim of the present study was to investigate the in vitro and in vivo efficiency of chemotherapy in combination with RFH for the treatment of prostate cancer. The following four treatment groups were included: i) No treatment (control); ii) RFH‑only; iii) chemotherapy (docetaxel)‑only; and iv) combination therapy of docetaxel and RFH in human prostate cancer (HPC) cell lines and mice with HPC xenografts. In the in vitro experiments, a heating guidewire was attached under the bottom of the last chamber of the four‑chamber cell culture slide, and was then connected to a radiofrequency (RF) generator. In the in vivo experiments, a tumor model was generated by subcutaneously injecting human prostate cancer cells into 24 male nu/nu mice. RFH was conducted by inserting the 0.022‑inch heating‑guidewire into the tumor. The follow‑up magnetic resonance imaging demonstrated a significant reduction in the average tumor size in animals treated with combination therapy compared with those receiving RFH‑only and chemotherapy‑only. The number of apoptotic cells and the average apoptotic index of the combination therapy group were significantly higher compared with those of the other three treatment groups. In conclusion, the results of the present study suggested that RFH is able to increase the therapeutic efficiency of docetaxel in prostate cancer, and this study serves as a foundation for the future development of an interventional molecular image‑guided local treatment strategy for prostate cancer that integrates RF technology, interventional oncology and direct intratumoral chemotherapy, as a replacement for systemic chemotherapy. AD - Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine and Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China Image‑Guided Bio‑Molecular Intervention Research and Section of Vascular and Interventional Radiology, Department of Radiology, University of Washington School of Medicine, Seattle, WA 98195, USA Department of Diagnostic Ultrasound and Echocardiography, Sir Run Run Shaw Hospital, Zhejiang University College of Medicine and Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China AU - Wu,Xia AU - Zhang,Feng AU - Hu,Peng AU - Chen,Lumin AU - Han,Guocan AU - Bai,Weixian AU - Luo,Jingfeng AU - Chen,Ran AU - Zhou,Yurong AU - Sun,Jihong AU - Yang,Xiaoming DA - 2017/12/01 DO - 10.3892/ol.2017.7145 EP - 7256 IS - 6 JO - Oncol Lett KW - prostate cancer radiofrequency docetaxel magnetic resonance imaging hyperthermia PY - 2017 SN - 1792-1074 1792-1082 SP - 7250 ST - Radiofrequency heat‑enhanced direct intratumoral chemotherapy for prostate cancer T2 - Oncology Letters TI - Radiofrequency heat‑enhanced direct intratumoral chemotherapy for prostate cancer UR - https://doi.org/10.3892/ol.2017.7145 VL - 14 ER -