TY - JOUR AB - We hypothesized that lysyl oxidase (LOX) contributes to the formation of fibrotic focus (FF) in association with inflammation and serves a significant role in breast carcinogenesis. In the present study, the association between the expression of LOX family members and FF with regards to with inflammation was analyzed, and the prognostic significance of LOX and FF in breast cancer was investigated. Immunohistochemical staining for LOX, LOX‑like protein (LOXL) 1, LOXL2 and LOXL3 was performed in primary breast cancer tissues. The status of FF within the tumor was assessed, including size and grade. Levels of inflammatory markers, intratumoral and peritumoral lymphocyte infiltration were also evaluated. The clinicopathological characteristics were evaluated from the medical records of patients. In the present study, the expression of LOX family members was not associated with the presence of FF. FF was identified to be associated with intratumoral and peritumoral inflammation, tumor stage, larger tumor size, lymph node metastasis, high histologic grade, and p53 expression. LOX and LOXL3 were associated with intratumoral, and peritumoral inflammation. Furthermore, LOXL1 was associated with intratumoral inflammation and interleukin‑4. In addition, LOX was associated with cluster of differentiation 8+ T cells. LOXL3 was associated with expression of ER and PR, and molecular subtype. In the survival analysis, overall survival time was statistically significantly longer in the FF‑negative compared with that in the FF‑positive group. In conclusion, it was demonstrated that FF and the expression of LOX family members were associated with inflammation in breast cancer. FF was associated with poor prognostic markers of breast cancer. Further studies are required to clarify the mechanisms underlying the association between the LOX family, FF and inflammation in breast cancer. AD - Department of Surgery, College of Medicine, Catholic University of Daegu, Daegu 705-718, Repulic of South Korea Department of Radiology, College of Medicine, Catholic University of Daegu, Daegu 705-718, Repulic of South Korea Department of Medical Statistics, College of Medicine, Catholic University of Daegu, Daegu 705-718, Repulic of South Korea Department of Pathology, College of Medicine, Catholic University of Daegu, Daegu 705-718, Repulic of South Korea AU - Jeong,Young ,Ju AU - Park,Sung ,Hwan AU - Mun,Sung ,Hee AU - Kwak,Sang ,Gyu AU - Lee,Sun‑Jae AU - Oh,Hoon ,Kyu DA - 2018/02/01 DO - 10.3892/ol.2017.7617 EP - 2440 IS - 2 JO - Oncol Lett KW - lysyl oxidase LOX fibrotic focus inflammation breast cancer PY - 2018 SN - 1792-1074 1792-1082 SP - 2431 ST - Association between lysyl oxidase and fibrotic focus in relation with inflammation in breast cancer T2 - Oncology Letters TI - Association between lysyl oxidase and fibrotic focus in relation with inflammation in breast cancer UR - https://doi.org/10.3892/ol.2017.7617 VL - 15 ER -