TY - JOUR AB - Previous studies have indicated that phospholipase A2 (PLA2) may be associated with tumorigenesis in human tissues. The present study aimed to investigate the association between plasma PLA2 activity and the breast cancer (BC) status of patients. Increased plasma PLA2 activity was detected in patients with breast cancer when compared with healthy controls. Plasma samples were obtained from patients with BC (n=169), patients with benign disease (BD; n=80) and healthy controls (n=81). PLA2 activity was assessed using a quantitative fluorescent assay with selective inhibitors. It was demonstrated that increased PLA2 and secretory PLA2 (sPLA2) activity was associated with tumor stage, particularly in patients with late‑stage disease. Additionally, smoking, alcohol consumption, body mass index (BMI) and age of patients did not have a significant effect on PLA2 activity. Analysis of receiver operating characteristic curves revealed that plasma PLA2 and sPLA2 activities were increased in BC patients compared with healthy controls. It was concluded that plasma PLA2 activity may serve as a biomarker for patients with BC. AD - The Second Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Department of Radiation Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China AU - Qu,Jingkun AU - Zhao,Xixi AU - Wang,Jizhao AU - Liu,Chao AU - Sun,Yuchen AU - Cai,Hui AU - Liu,Jianlin DA - 2018/04/01 DO - 10.3892/ol.2018.7915 EP - 5242 IS - 4 JO - Oncol Lett KW - phospholipase A2 secretory phospholipase A2 breast cancer biomarker plasma PY - 2018 SN - 1792-1074 1792-1082 SP - 5236 ST - Plasma phospholipase A2 activity may serve as a novel diagnostic biomarker for the diagnosis of breast cancer T2 - Oncology Letters TI - Plasma phospholipase A2 activity may serve as a novel diagnostic biomarker for the diagnosis of breast cancer UR - https://doi.org/10.3892/ol.2018.7915 VL - 15 ER -