TY - JOUR AB - microRNAs (miRNAs) perform various oncogenic or tumor suppressor functions in carcinogenesis. Currently, the underlying mechanisms of miRNAs in osteosarcoma (OS) are poorly understood. In the present study, it is demonstrated that expression of miR‑544 was markedly upregulated in OS cells and clinical tissues. Furthermore, overexpression of miR‑544 enhanced OS cell proliferation in vitro. Bioinformatics analysis indicated that miR‑544 may target the 3'‑untranslated region of axis formation inhibitor 2, which was validated using luciferase reporter gene assays. The present study demonstrated a vital role for miR‑544 in promoting OS cell proliferation, indicating that it may represent a novel prognostic factor or therapeutic target for OS. AD - Department of Orthopedics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China AU - Chen,Ming AU - Liu,Yong‑Yi AU - Zheng,Min‑Qing AU - Wang,Xin‑Liang AU - Gao,Xing‑Hua AU - Chen,Lin AU - Zhang,Guang‑Ming DA - 2018/05/01 DO - 10.3892/ol.2018.8218 EP - 7082 IS - 5 JO - Oncol Lett KW - microRNA‑544 osteosarcoma axis formation inhibitor 2 cell proliferation PY - 2018 SN - 1792-1074 1792-1082 SP - 7076 ST - microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression T2 - Oncology Letters TI - microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression UR - https://doi.org/10.3892/ol.2018.8218 VL - 15 ER -