TY - JOUR AB - In the present study, the effects of microRNA‑29a (miRNA‑29a) on colon cancer cell viability and the molecular mechanisms underlying the effects were investigated. The expression of miRNA‑29a in colon cancer serum samples was notably downregulated, compared with in the normal group. First, miRNA‑29a mimic was used to increase the expression of miRNA‑29a in HCT‑116 cells. Furthermore, upregulation of miRNA‑29a suppressed cell viability, increased lactate dehydrogenase levels and apoptosis, and promoted caspase‑3/9 activities and B‑cell lymphoma 2‑associated X protein and phosphatase and tensin homolog (PTEN) protein expression in colon cancer cells. Furthermore, upregulation of miRNA‑29a decreased phosphoinositide 3‑kinase, phosphorylated (p)‑protein kinase B (Akt) and p‑glycogen synthase kinase 3β (GSK3β) protein expression and suppressed the Wnt/β‑catenin signaling pathway in colon cancer cells. The results of the present study verified that the protective effects of miRNA‑29a suppress the PTEN/Akt/GSK3β and Wnt/β‑catenin signaling pathways in colon cancer. AD - Department of General Surgery, Beijing Chao‑Yang Hospital, Capital Medical University, Beijing 100043, P.R. China AU - Han,Xiaofeng AU - Zheng,Jianwei AU - Wang,Yunlei AU - Gao,Zhigang DA - 2018/08/01 DO - 10.3892/ol.2018.8905 EP - 2644 IS - 2 JO - Oncol Lett KW - microRNA‑29a colon cancer phosphatase and tensin homolog/protein kinase B/glycogen synthase kinase 3β Wnt/β‑catenin PY - 2018 SN - 1792-1074 1792-1082 SP - 2638 ST - miRNA‑29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3β and Wnt/β‑catenin signaling pathways T2 - Oncology Letters TI - miRNA‑29a inhibits colon cancer growth by regulation of the PTEN/Akt/GSK3β and Wnt/β‑catenin signaling pathways UR - https://doi.org/10.3892/ol.2018.8905 VL - 16 ER -