TY - JOUR AB - Malignant brain tumor domain containing protein 1 (MBTD1) is a member of the polycomb group protein family that is associated with tumorigenesis. The present study investigated the role of MBTD1 within defined clinicopathological parameters and the prognosis of patients with prostate cancer (PCa). A human tissue microarray containing samples from 71 patients with PCa and seven healthy donors was employed for immunohistochemistry (IHC). The clinicopathological characteristics and prognostic value of MBTD1 were investigated using a dataset of 499 patients from The Cancer Genome Atlas (TCGA). IHC illustrated that the levels of MBTD1 protein were enhanced and markedly associated with aggressive clinical stage and advanced tumor invasion, distant metastasis and lymph node metastasis in patients with PCa. In the TCGA data set, the level of MBTD1 was found to positively correlate with the prostate‑specific antigen level, Gleason score and distant metastasis. The multivariate analysis of Cox regression revealed that the levels of MBTD1 may act as an independent prognostic factor for low non‑biochemical, recurrence‑free survival. In conclusion, MBTD1 was overexpressed in PCa tissues and is associated with aggressive clinicopathological characteristics. It may therefore act as a novel prognostic factor and diagnostic marker in PCa. AD - Department of Urology, The Sun Yat‑Sen Memorial Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA AU - Wu,Wanhua AU - Bai,Shoumin AU - Zhu,Dingjun AU - Li,Kaiwen AU - Dong,Wen AU - He,Wang AU - Peng,Shengmeng AU - Lai,Yiming AU - Wang,Qiong AU - Guo,Zhenghui AU - Liu,Leyuan AU - Huang,Hai DA - 2019/05/01 DO - 10.3892/ol.2019.10109 EP - 4646 IS - 5 JO - Oncol Lett KW - MBTD1 metastasis prognosis prostate carcinoma survival PY - 2019 SN - 1792-1074 1792-1082 SP - 4640 ST - Overexpression of malignant brain tumor domain containing protein 1 predicts a poor prognosis of prostate cancer T2 - Oncology Letters TI - Overexpression of malignant brain tumor domain containing protein 1 predicts a poor prognosis of prostate cancer UR - https://doi.org/10.3892/ol.2019.10109 VL - 17 ER -