TY - JOUR AB - Interest in cancer metabolism has increased in recent years. The pentose phosphate pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its oxidative branch and leads to the production of a reduced form of nicotinamide adenine dinucleotide phosphate and nucleic acid. The PPP serves a vital role in regulating cancer cell growth and involves many enzymes. The aim of the present review was to describe the recent discoveries associated with the deregulatory mechanisms of the PPP and glycolysis in malignant tumors, particularly in hepatocellular carcinoma, breast and lung cancer. AD - The Key Laboratory of Carcinogenesis of The Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China AU - Jin,Lin AU - Zhou,Yanhong DA - 2019/05/01 DO - 10.3892/ol.2019.10112 EP - 4221 IS - 5 JO - Oncol Lett KW - pentose phosphate pathway glycolysis hepatocellular carcinoma breast cancer PY - 2019 SN - 1792-1074 1792-1082 SP - 4213 ST - Crucial role of the pentose phosphate pathway in malignant tumors (Review) T2 - Oncology Letters TI - Crucial role of the pentose phosphate pathway in malignant tumors (Review) UR - https://doi.org/10.3892/ol.2019.10112 VL - 17 ER -