TY - JOUR AB - Desmoplastic melanoma (DM) is a rare morphological subtype of melanoma that remains uncharacterized. The aim of the present study was to investigate the incidence of DM, its general demographics, clinicopathological features and disease‑specific prognostic factors. DM cases were sampled from the Surveillance, Epidemiology and End Results (SEER) program from between 1973 and 2017. A total of 3,657 cases (median age, 68 years) were identified. The results indicated that DM primarily occurred in Caucasian subjects, with a male‑to‑female ratio of 2:1. Statistically significant overall survival (OS) and disease‑specific survival (DSS) rate differences were identified according to sex, age, treatment, T stage, N stage and SEER historic tumor stage (P<0.05). In multivariate Cox regression analysis, age >68 years, male sex, American Joint Committee on Cancer (AJCC) stage II and III, and SEER historic tumor stage of the regional tumor were all factors associated with poorer OS and DSS rates. The findings also revealed that surgical treatment was associated with favorable DSS and OS rates. In conclusion, DM occurred primarily in Caucasian subjects of 60‑80 years of age, with predominance in males. Furthermore, age, sex, AJCC stage, SEER historic tumor stage and surgical treatment were identified as independent prognostic factors of DM in terms of DSS and OS. AD - Department of Stomatology, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong 518110, P.R. China Department of Preventive Medicine, School of Public Health, Fudan University, Shanghai 200001, P.R. China Department of Oral and Maxillofacial Surgery, Shanghai Stomatological Hospital, Fudan University, Shanghai 200001, P.R. China AU - Shi,Ping AU - Xu,Zhe AU - Lei,Xin AU - Yibulayin,Feiluore AU - Wushou,Alimujiang DA - 2019/06/01 DO - 10.3892/ol.2019.10259 EP - 5627 IS - 6 JO - Oncol Lett KW - desmoplastic melanoma incidence prognostic factor Surveillance Epidemiology and End Results PY - 2019 SN - 1792-1074 1792-1082 SP - 5619 ST - Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors T2 - Oncology Letters TI - Desmoplastic melanoma: Demographic and clinicopathological features and disease‑specific prognostic factors UR - https://doi.org/10.3892/ol.2019.10259 VL - 17 ER -