TY - JOUR AB - Cervical cancer is the fourth most common type of gynecological malignancy to affect females, worldwide. Although high‑risk human papillomavirus (HR‑HPV) infection is the primary etiologic agent associated with the development of cervical cancer, cancer stem cells (CSCs) also serve a prominent role in the development, metastasis, recurrence and prognosis of the disease. CSCs are a small subpopulation of cells that have the ability to self‑renew and are present in the majority of tumors, including cervical cancer. Studies describing the phenotype of cervical CSCs (CCSCs) vary in their definition of the expression pattern of principal biomarkers, including Musashi‑1, aldehyde dehydrogenase 1, Oct3/4, Sox2 and CD49f. However, these markers are not observed in all cancers, although several may be present in multiple tumor types. The present review describes the potential biomarkers of CSCs in cervical cancer. These CCSC biomarkers may serve as molecular targets to enhance the efficacy and reduce the side effects associated with chemotherapeutic treatment in HR‑HPV‑positive cervical cancer. AD - Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero 39090, Mexico AU - Organista‑Nava,Jorge AU - Gómez‑Gómez,Yazmín AU - Garibay‑Cerdenares,Olga ,Lilia AU - Leyva‑Vázquez,Marco ,Antonio AU - Illades‑Aguiar,Berenice DA - 2019/07/01 DO - 10.3892/ol.2019.10307 EP - 14 IS - 1 JO - Oncol Lett KW - cervical cancer stem cells high‑risk human papillomavirus transformation zone biomarkers PY - 2019 SN - 1792-1074 1792-1082 SP - 7 ST - Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review) T2 - Oncology Letters TI - Cervical cancer stem cell‑associated genes: Prognostic implications in cervical cancer (Review) UR - https://doi.org/10.3892/ol.2019.10307 VL - 18 ER -