TY - JOUR AB - The present study evaluated the role of annexin A1 (ANXA1) in the treatment of acute radiation‑induced lung injury (RILI) and investigated the mechanism of its action. The expression of ANXA1, interleukin‑6 (IL‑6) and myeloperoxidase (MPO) in the plasma of patients with RILI prior to and following hormonotherapy was assessed by enzyme‑linked immunosorbent assay. The association of plasma ANXA1 concentration with clinical effect, and the correlation between the expression of ANXA1 and that of IL‑6 and MPO were evaluated. ANXA1 was overexpressed or knocked down in a macrophage cell line, and its impact on IL‑6 and MPO expression was measured. Following glucocorticoid hormonotherapy, patients with RILI exhibited a higher plasma concentration of ANXA1 compared with that prior to treatment, while IL‑6 and MPO levels were lower. The concentration of ANXA1 in plasma was negatively correlated with IL‑6 and MPO levels, with a correlation coefficient of ‑0.492 and ‑0.437, respectively (P<0.001). The increasing concentration of ANXA1 in plasma following treatment was associated with the clinical effect in patients with RILI (P=0.007). The expression levels of of IL‑6 and MPO were inhibited both in the cytoplasm and in the culture solution, when ANXA1 expression was upregulated in a macrophage cell line. In conclusion, ANXA1 inhibited the synthesis and secretion of IL‑6 and MPO inflammatory cytokines, indicating that ANXA1 may have therapeutic potential as a treatment target for RILI. AD - Department of Oncology, The Fifth Affiliated Hospital of Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China Department of Thoracic Surgery, The Fifth Affiliated Hospital of Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China Radiation Therapy Center, The Fifth Affiliated Hospital of Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China Medical Imaging Center, The Fifth Affiliated Hospital of Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China Central Laboratory, The Fifth Affiliated Hospital of Nantong University, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China AU - Han,Gaohua AU - Lu,Kaijin AU - Xu,Wansong AU - Zhang,Sihui AU - Huang,Junxing AU - Dai,Chunlei AU - Sun,Guangzhi AU - Ye,Jun DA - 2019/07/01 DO - 10.3892/ol.2019.10317 EP - 329 IS - 1 JO - Oncol Lett KW - annexin A1 interleukin‑6 myeloperoxidase radiation‑​induced lung injury PY - 2019 SN - 1792-1074 1792-1082 SP - 321 ST - Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury T2 - Oncology Letters TI - Annexin A1‑mediated inhibition of inflammatory cytokines may facilitate the resolution of inflammation in acute radiation‑induced lung injury UR - https://doi.org/10.3892/ol.2019.10317 VL - 18 ER -