TY - JOUR AB - Long non‑coding RNA (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) serves roles as a tumor suppressor or oncogene in different types of cancer. The current study aimed to explore the role of DGCR5 in colorectal cancer (CRC). It was revealed that the expression of DGCR5 was downregulated, while microRNA (miR)‑21 was upregulated in CRC. The expression level of DGCR5 in tumor tissue decreased, while expression levels of miR‑21 increased, with advancing stages of the disease. The expression levels of DGCR5 and miR‑21 were inversely associated in tumor tissues. In CRC cells in vitro, miR‑21 overexpression failed to significantly affect DGCR5, while DGCR5 overexpression resulted in reduced expression levels of miR‑21. DGCR5 overexpression showed no significant effects on cancer cell migration and invasion, but suppressed cancer cell proliferation in vitro. miR‑21 overexpression increased cancer cell proliferation and attenuated the effects of DGCR5 overexpression. Therefore, lncRNA DGCR5 may inhibit the proliferation of CRC cells by downregulating miR‑21. AD - Department of Medical Oncology, The Second Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou, Guangxi 545006, P.R. China Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China AU - Huang,Hansheng AU - Yang,Xiaomei AU - Chen,Jun AU - Fu,Junmin AU - Chen,Chaoting AU - Wen,Jianmei AU - Mo,Qiao DA - 2019/09/01 DO - 10.3892/ol.2019.10671 EP - 3336 IS - 3 JO - Oncol Lett KW - colorectal cancer long non‑coding RNA DiGeorge syndrome critical region gene 5 microRNA‑21 PY - 2019 SN - 1792-1074 1792-1082 SP - 3331 ST - lncRNA DGCR5 inhibits the proliferation of colorectal cancer cells by downregulating miR‑21 T2 - Oncology Letters TI - lncRNA DGCR5 inhibits the proliferation of colorectal cancer cells by downregulating miR‑21 UR - https://doi.org/10.3892/ol.2019.10671 VL - 18 ER -