TY - JOUR AB - Despite the incidence rates of pancreatic cancer being low worldwide, the mortality rates remain high. To date, there is no effective drug treatment for pancreatic cancer. Numerous signalling pathways and cytokines regulate the occurrence and development of pancreatic cancer. Ferroptosis is a non‑traditional form of cell death resulting from iron‑dependent lipid peroxide accumulation. Studies have demonstrated that ferroptosis is associated with a variety of different types of cancer, such as breast cancer, hepatocellular carcinoma and pancreatic cancer. The present study demonstrated that ferroptosis controls the growth and proliferation of pancreatic cancer, providing a new approach for the treatment of pancreatic cancer. Iron metabolism and reactive oxygen species metabolism are the key pathways involved in ferroptosis in pancreatic cancer. In addition, a number of regulators of ferroptosis, such as glutathione peroxidase 4 and the cystine/glutamate antiporter system Xc‑, also play pivotal roles in the regulation of ferroptosis. In the present review, the regulatory mechanisms associated with ferroptosis in pancreatic cancer are summarized, alongside other associated forms of digestive system cancer. The treatment of ferroptosis‑based diseases is also addressed. AD - Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China AU - Chen,Gang AU - Guo,Guangqi AU - Zhou,Xiaodong AU - Chen,Hongxia DA - 2020/01/01 DO - 10.3892/ol.2019.11159 EP - 587 IS - 1 JO - Oncol Lett KW - ferroptosis pancreatic cancer iron reactive oxygen species treatment PY - 2020 SN - 1792-1074 1792-1082 SP - 579 ST - Potential mechanism of ferroptosis in pancreatic cancer (Review) T2 - Oncology Letters TI - Potential mechanism of ferroptosis in pancreatic cancer (Review) UR - https://doi.org/10.3892/ol.2019.11159 VL - 19 ER -