TY - JOUR AB - A recent study characterized the long non‑coding RNA (lncRNA) ELF3‑antisense RNA 1 (ELF3‑AS1) as an oncogenic lncRNA in bladder cancer. The present study aimed to investigate the role of ELF3‑AS1 in osteosarcoma (OS). It was found that ELF3‑AS1 was upregulated in OS tissues, and ELF3‑AS1 expression level increased with increasing clinical stage. In OS tissues, Kruppel‑like factor 12 (KLF12) was positively correlated with ELF3‑AS1, while microRNA (miR)‑205 was negatively correlated with ELF3‑AS1. ELF3‑AS1 overexpression resulted in the upregulation of KLF12, but the downregulation of miR‑205. Overexpression of miR‑205 caused downregulation of KLF12, but had no significant effects on ELF3‑AS1 expression. Overexpression of KLF12 showed no significant impact on ELF3‑AS1 and miR‑205. ELF3‑AS1 and KLF12 overexpression resulted in an increased proliferation rate in OS cells, while miR‑205 played an opposite role and attenuated the effects of ELF3‑AS1 overexpression. ELF3‑AS1 overexpression promoted the methylation of the miR‑205 gene. Therefore, ELF3‑AS1 may promote OS cell proliferation by upregulating KLF12 through the methylation of the miR‑205 gene. AD - Department of Orthopedics and Traumatology, First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China Department of Cardiology, First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China AU - Yuan,Jianmin AU - Kang,Jianhui AU - Yang,Min DA - 2020/03/01 DO - 10.3892/ol.2020.11312 EP - 2480 IS - 3 JO - Oncol Lett KW - osteosarcoma Kruppel‑like factor 12 long non‑coding RNA ELF3‑antisense RNA 1 microRNA‑205 PY - 2020 SN - 1792-1074 1792-1082 SP - 2475 ST - Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene T2 - Oncology Letters TI - Long non‑coding RNA ELF3‑antisense RNA 1 promotes osteosarcoma cell proliferation by upregulating Kruppel‑like factor 12 potentially via methylation of the microRNA‑205 gene UR - https://doi.org/10.3892/ol.2020.11312 VL - 19 ER -