TY - JOUR AB - Long non‑coding RNAs (lncRNAs) are functional components of the human genome. Recent studies have demonstrated that lncRNAs play essential roles in tumorigenesis, and are involved in cell proliferation, apoptosis, migration and invasion in several types of tumor, including lung cancer. However, the clinical relevance of lncRNA expression in lung cancer remains unknown. The aim of the present study was to investigate the expression pattern of RFPL3 antisense (RFPL3S) and its associations with clinicopathological characteristics in patients with lung cancer. Whether RFPL3S can act as a potential prognostic biomarker for lung cancer was also investigated. RFPL3S expression in tumor samples and cells was assessed using the Oncomine database and the Cancer Cell Line Encyclopedia, respectively. Based on Kaplan‑Meier Plotter analyses, the prognostic values of RFPL3S were further evaluated. It was revealed that RFPL3S was highly expressed in lung cancer tissues when compared with normal tissues and was significantly associated with pN factor, pTNM stage and Ki‑67 labeling index. In the survival analyses, increased RFPL3S expression was associated with poor survival and was inversely associated with first progression in all patients. These results indicate that RFPL3S may be of clinical significance and may act as a prognostic biomarker in lung cancer. AD - Department of Oncology, Suzhou Ninth People's Hospital, Suzhou, Jiangsu 215200, P.R. China Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China AU - Liu,Zhonghua AU - Ning,Zhiqiang AU - Lu,Hailin AU - Cao,Tinghua AU - Zhou,Feng AU - Ye,Xia AU - Chen,Chao DA - 2020/08/01 DO - 10.3892/ol.2020.11642 EP - 1280 IS - 2 JO - Oncol Lett KW - lung cancer lncRNA RFPL3S biomarker prognosis PY - 2020 SN - 1792-1074 1792-1082 SP - 1270 ST - Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer T2 - Oncology Letters TI - Long non‑coding RNA RFPL3S is a novel prognostic biomarker in lung cancer UR - https://doi.org/10.3892/ol.2020.11642 VL - 20 ER -