TY - JOUR AB - S phase kinase‑associated protein 2 (SKP2), a substrate recognizing protein, serves an important role in promoting cell cycle progression through ubiquitination and degradation of cell cycle inhibitors. In the present study, the clinical significance of SKP2 in gliomas was studied; 395 glioma specimens and 20 non‑neoplastic tissues were collected and immunohistochemical analysis was performed. χ2 test was used to assess the associations between SKP2 expression and clinical parameters. Overall survival (OS) curves were plotted according to the Kaplan‑Meier method. In the tested glioma samples, SKP2 expression was mainly observed in glioblastomas (GBMs). Survival analysis demonstrated that the overall survival time of the high SKP2 expression group was lower compared with the low SKP2 expression group (median OS, 10.04 months vs. 16.50 months; P=0.003). Moreover, SKP2 was independently associated with an unfavorable prognosis in GBMs. In addition, the expression of SKP2 was associated with the expression of phosphorylated retinoblastoma protein and the epidermal growth factor receptor. A combination of SKP2 expression along with isocitrate dehydrogenase 1 (IDH1) mutations and telomerase reverse transcriptase (TERT) promoter mutations was used to classify glioma patients for survival analysis. Patients with low SKP2 expression, IDH1 mutation and wild‑type TERT promoter demonstrated the longest survival time. The findings of the present study, indicate that SKP2 is a potential prognostic biomarker in patients with GBMs. AD - Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China Department of Neurosurgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China Department of State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China AU - Cheng,Zhi‑Jian AU - Cai,Hong‑Qing AU - Zhang,Min‑Jie AU - Zhong,Yi AU - He,Jie AU - Yuan,Qing AU - Hao,Jia‑Jie AU - Wang,Ming‑Rong AU - Wan,Jing‑Hai DA - 2020/09/01 DO - 10.3892/ol.2020.11818 EP - 2796 IS - 3 JO - Oncol Lett KW - glioma S phase kinase‑associated protein 2 immuno-histochemistry biomarker prognosis PY - 2020 SN - 1792-1074 1792-1082 SP - 2788 ST - High S phase kinase‑associated protein 2 expression is a potential prognostic biomarker for glioma T2 - Oncology Letters TI - High S phase kinase‑associated protein 2 expression is a potential prognostic biomarker for glioma UR - https://doi.org/10.3892/ol.2020.11818 VL - 20 ER -