TY - JOUR AB - X‑linked ubiquitin‑specific peptidase 9 (USP9X) serves important roles in the development and progression of various human cancers. However, its role and molecular mechanism in liver cancer require further elucidation. In the present study, USP9X was found to be upregulated in liver cancer tissues. At the same time, overexpression of USP9X promoted the proliferation, invasiveness and migration of liver cancer cells, which were subsequently suppressed by USP9X silencing. On a molecular level, the results revealed that USP9X knockdown suppressed elements of the Janus kinase 2 (JAK2)/STAT3 signaling pathway, including JAK2, STAT3, matrix metalloproteinase‑2 and c‑Myc. By contrast, overexpression of USP9X had the opposite effect. In conclusion, the results of the present study suggest that USP9X is upregulated in patients with liver cancer, which may accelerate the proliferation, invasiveness and migration of liver cancer cells by regulating the JAK2/STAT3 signaling pathway. AD - Department of General Surgery, Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China AU - Song,Xingchao AU - Yang,Weibin AU - Wu,Chao AU - Han,Yamin AU - Lu,Yaowu DA - 2020/09/01 DO - 10.3892/ol.2020.11824 EP - 2905 IS - 3 JO - Oncol Lett KW - liver cancer X‑linked ubiquitin‑specific peptidase 9 Janus kinase 2 STAT3 PY - 2020 SN - 1792-1074 1792-1082 SP - 2897 ST - USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling T2 - Oncology Letters TI - USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling UR - https://doi.org/10.3892/ol.2020.11824 VL - 20 ER -