TY - JOUR AB - Liver cancer (LC) is one of the primary contributors of cancer‑associated death worldwide. Long non‑coding RNAs (lncRNAs) have been shown to participate in almost every aspect of cell biology and serve fundamental roles in carcinogenesis and cancer progression, including in LC. However, the clinical significance and functional role of the lncRNA breast cancer anti‑estrogen resistance 4 (BCAR4) in LC have not yet been identified. The present study measured the expression levels of BCAR4 in LC cells and tissues, and discovered that BCAR4 was upregulated in LC tissues compared with adjacent normal tissues. Furthermore, high BCAR4 expression was associated with the presence of multiple tumors and advanced Tumor‑Node‑Metastasis stages (III/IV). Survival analysis found that high BCAR4 expression indicated poor overall survival (OS) and progression‑free survival (PFS). By analyzing the risk factors of poor OS and PFS using univariate analysis and multivariate analysis, high BCAR4 expression was revealed to be an independent risk factor of poor prognosis. In addition, the role of BCAR4 was further investigated in vitro, which revealed overexpression of BCAR4 to markedly promote the proliferation, migration and invasion of LC cells. Conversely, the loss of BCAR4 expression repressed the proliferation, migration and invasion of LC cells. In conclusion, BCAR4 is overexpressed in LC and is associated with LC progression. Therefore, BCAR4 may be used as a potential prognostic marker in LC. AD - Department of Gastroenterology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Orthopedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, P.R. China Department of Oncology, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi 330006, P.R. China AU - Wang,Aiyao AU - Meng,Jun AU - Liu,Hui AU - Li,Chen AU - Zhou,Zhiyong DA - 2020/09/01 DO - 10.3892/ol.2020.11826 EP - 2787 IS - 3 JO - Oncol Lett KW - BCAR4 hepatocellular cancer prognosis PY - 2020 SN - 1792-1074 1792-1082 SP - 2779 ST - Long non‑coding RNA BCAR4 promotes liver cancer progression by regulating proliferation, migration and invasion T2 - Oncology Letters TI - Long non‑coding RNA BCAR4 promotes liver cancer progression by regulating proliferation, migration and invasion UR - https://doi.org/10.3892/ol.2020.11826 VL - 20 ER -