TY - JOUR AB - To date, >650 E3 ubiquitin ligases have been described in humans, including >600 really interesting new genes (RINGs), 28 homologous to E6‑associated protein C‑terminus (HECTs) and several RING‑in‑between‑RINGs. They are considered key regulators and therapeutic targets of many types of human cancers, including gastric cancer (GC). Among them, some RING and HECT E3 ligases are closely related to the proliferation, infiltration and prognosis of GC. During the past few years, abnormal expressions and functions of many E3 ligases have been identified in GC. However, the functional roles of E3 ligases in GC have not been fully elucidated. The present article focuses on the functional roles of E3 ligases related to the proteasome in GC. In this comprehensive review, the latest research progress on E3 ligases involved in GC and elaborate their structure, classification, functional roles and therapeutic value in GC was summarized. Finally, 30 E3 ligases that serve essential roles in regulating the development of GC were described. Some of these ligases may serve as oncogenes or tumor suppressors in GC, whereas the pathological mechanism of others needs further study; for example, constitutive photomorphogenic 1. In conclusion, the present review demonstrated that E3 ligases are crucial tumor regulatory factors and potential therapeutic targets in GC. Therefore, more studies should focus on the therapeutic targeting of E3 ligases in GC. AD - Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China Department of Geriatric Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China AU - Wang,Mingliang AU - Dai,Wei AU - Ke,Zhangyan AU - Li,Yongxiang DA - 2020/10/01 DO - 10.3892/ol.2020.11883 IS - 4 JO - Oncol Lett KW - gastric cancer E3 ligases targeted therapy ubiquitin signaling pathways PY - 2020 SN - 1792-1074 1792-1082 SP - 22 ST - Functional roles of E3 ubiquitin ligases in gastric cancer (Review) T2 - Oncology Letters TI - Functional roles of E3 ubiquitin ligases in gastric cancer (Review) UR - https://doi.org/10.3892/ol.2020.11883 VL - 20 ER -