TY - JOUR AB - Breast cancer is a complex disease posing a serious threat to the female population worldwide. A complex molecular landscape and tumor heterogeneity render breast cancer cells resistant to drugs and able to promote metastasis and invasiveness. Despite the recent advancements in diagnostics and drug discovery, finding an effective cure for breast cancer is still a major challenge. Positive and negative regulation of apoptosis has been a subject of extensive study over the years. Numerous studies have shed light on the mechanisms that impede the tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) signaling cascade. Long non‑coding RNAs (lncRNAs) have been implicated in the orchestration, development, proliferation, differentiation and metastasis of breast cancer. However, the roles of lncRNAs in fine‑tuning apoptosis regulating machinery in breast cancer remain to be elucidated. The present review illuminates the roles of these molecules in the regulation of breast cancer and the interplay between lncRNA and TRAIL in breast cancer. The present review also attempts to reveal their role in the regulation of apoptosis in breast cancer appears a promising approach for the development of new diagnostic and therapeutic regimens. AD - Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Punjab 54792, Pakistan Atta‑ur‑Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Punjab 44000, Pakistan Center for Excellence in Molecular Biology, University of the Punjab, Lahore, Punjab 53700, Pakistan Institute of Microbiology, University of Veterinary and Animal Sciences, Lahore, Punjab 54000, Pakistan Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Punjab 54000, Pakistan Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Balochistan 87100, Pakistan Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam 44340847, Iran Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, P.R. China AU - Javed,Zeeshan AU - Khan,Khushbukhat AU - Iqbal,Muhammad,Zaheer AU - Ahmad,Touqeer AU - Raza,Qamar AU - Sadia,Haleema AU - Raza,Shahid AU - Salehi,Bahare AU - Sharifi‑Rad,Javad AU - Cho,William,C. DA - 2020/10/01 DO - 10.3892/ol.2020.11896 IS - 4 JO - Oncol Lett KW - long non‑coding RNA tumor necrosis factor‑related apoptosis‑inducing ligand diagnosis therapeutics breast cancer PY - 2020 SN - 1792-1074 1792-1082 SP - 37 ST - Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review) T2 - Oncology Letters TI - Long non‑coding RNA regulation of TRAIL in breast cancer: A tangle of non‑coding threads (Review) UR - https://doi.org/10.3892/ol.2020.11896 VL - 20 ER -