TY - JOUR AB - Long non‑coding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs), interacting with microRNAs (miRNAs) and playing an important role in tumor progression. However, the role of lncRNA‑mediated ceRNAs in glioma remains largely unknown. The present study aimed to identify novel lncRNAs and their associated function in glioma. RNA sequencing and corresponding clinical data from patients with glioma were obtained from The Cancer Genome Atlas. A total of 598 glioma tissues and 5 normal brain tissues were analyzed in the present study. The differentially expressed (DE) lncRNAs, mRNAs and miRNAs were identified using R packages and were used to construct a ceRNA network. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to investigate the biological functions of the DEmRNAs. Kaplan‑Meier curve analysis was performed to investigate the association between DElncRNA expression and patient outcome. A total of 752 DElncRNAs, 2,079 DEmRNAs and 113 DEmiRNAs were identified between glioma and normal tissues. A lncRNA‑miRNA‑mRNA ceRNA network consisting of 61 lncRNAs, 12 miRNAs and 92 mRNAs was constructed. Survival analysis indicated that 36 DElncRNAs, 72 DEmRNAs and 3 DEmiRNAs were associated with overall survival in patients with glioma. The present study identified novel lncRNAs associated with survival prognosis and may facilitate further investigation of lncRNA‑mediated ceRNA regulatory mechanisms in glioma. AD - Department of Oncology, Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu 213003, P.R. China Department of Oncology, Jining Cancer Hospital, Jining, Shandong 272000, P.R. China Department of General Practice, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China Department of Intervention and Vascular Surgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China Department of Oncology, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China Department of Radio‑Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China Department of Neurosurgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China AU - Zhu,Jie AU - Wang,Han AU - Huang,Yue-Qing AU - Song,Wei AU - Li,Yi-Fan AU - Wang,Wen-Jie AU - Ding,Zhi-Liang DA - 2020/10/01 DO - 10.3892/ol.2020.11924 IS - 4 JO - Oncol Lett KW - glioma competitive endogenous RNA long non‑coding RNA survival analysis PY - 2020 SN - 1792-1074 1792-1082 SP - 63 ST - Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma T2 - Oncology Letters TI - Comprehensive analysis of a long non‑coding RNA‑associated competing endogenous RNA network in glioma UR - https://doi.org/10.3892/ol.2020.11924 VL - 20 ER -