TY - JOUR AB - Reliable biomarkers for the prognosis of hepatocellular carcinoma (HCC) are rare, and novel biomarkers are required for the appropriate management of HCC. 5'‑Nucleotidase domain containing 2 (NT5DC2) acts as an oncogene in various tumors, but its functions as a biomarker have not been confirmed. Therefore, the present study aimed to resolve these functions by analyzing the prognostic value of NT5DC2 in patients with HCC. A tissue microarray (TMA) was prepared and NT5DC2 expression was measured via IHC staining in TMA dots. The liver cancer (LIHC) cohort in The Cancer Genome Atlas (TCGA) was enrolled as a secondary cohort. Kaplan‑Meier survival analyses and Cox regression models were used for assessment of the prognostic value of NT5DC2. Gene set enrichment analysis (GSEA) was performed in TCGA LIHC cohort. A total of 134 patients with HCC were retrospectively enrolled in the Peking Union Medical College Hospital cohort and clinical data were collected. A total of 359 patients with HCC in TCGA were enrolled as TCGA cohort. NT5DC2 was used as an indicator of overall survival (OS) and relapse‑free survival (RFS) in multiple cohorts. In the multivariate Cox regression model, NT5DC2 upregulation was an independent prognostic factor of OS in both cohorts. GSEA indicated the enrichment of a series of survival‑ and metastasis‑related gene‑sets, such as LEE_LIVER_CANCER_SURVIVAL_UP and LIAO_METASTASIS. Collectively, it was suggested that NT5DC2 upregulation was associated with poor OS and RFS in HCC, and was a potential predictive marker for HCC stratification. AD - Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China Department of General Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China AU - Chen,Jiemin AU - Cao,Jianzhong AU - Wang,Penghui AU - He,Xiaodong DA - 2020/10/01 DO - 10.3892/ol.2020.11931 IS - 4 JO - Oncol Lett KW - hepatocellular carcinoma prognostic marker 5'‑nucleotidase domain containing 2 overall survival cancer biomarker PY - 2020 SN - 1792-1074 1792-1082 SP - 70 ST - NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma T2 - Oncology Letters TI - NT5DC2 is a novel prognostic marker in human hepatocellular carcinoma UR - https://doi.org/10.3892/ol.2020.11931 VL - 20 ER -