TY - JOUR AB - Gastric cancer (GC) is one of the most frequently diagnosed gastrointestinal cancer types in the world. Novel prognostic biomarkers are required to predict the progression of GC. Glutathione S‑transferase Mu (GSTM) belongs to a family of phase II enzymes that have been implicated in a number of cancer types. However, the prognostic value of the GSTM genes has not been previously investigated in GC. The Cancer Genome Atlas (TCGA) was used to evaluate mRNA expression levels of GSTMs in GC tissue samples. Overall survival (OS) rates, hazard ratios (HRs) and 95% CIs were calculated using the Cox logistic regression model and Kaplan‑Meier (KM) analysis was performed. In addition, the KM plotter online database was used to validate mRNA expression and the prognostic value of GSMT family members in patients with GC. To predict the function of GSTM genes in these patients, several bioinformatics tools, including the Database for Annotation, Visualization and Integrated Discovery, gene multiple association network integration algorithm, Search Tool for the Retrieval of Interacting Genes/Proteins, Gene Set Enrichment Analysis (GSEA), nomogram and genome‑wide co‑expression analysis were used. In the present study, high expression of GSTM5 was indicated to be strongly associated with lower OS in patients with GC, according to the TCGA and KM plotter online databases (HR=1.47, 95% CI: 1.06‑2.04, P=0.021; and HR=1.69, 95% CI: 1.42‑2.01, P=1.6x10‑9, respectively). The results from the GSEA and genome‑wide co‑expression analysis indicated that GSTM5 expression associated with several biological process terms, including ‘adhesion’, ‘angiogenesis’, ‘apoptotic process’, ‘cell growth’, ‘proliferation’, ‘migration’, ‘Hedgehog signaling’, ‘MAPK signaling’ and the ‘TGF‑β signaling pathway’. In conclusion, the present results indicated that GSTM5 may serve as a biomarker for GC prognosis and may be a potential therapeutic target for GC. AD - Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China AU - Chen,Yeyang AU - Li,Bopei AU - Wang,Junfu AU - Liu,Jinlu AU - Wang,Zhen AU - Mao,Yuantian AU - Liu,Siyu AU - Liao,Xiwen AU - Chen,Junqiang DA - 2020/10/01 DO - 10.3892/ol.2020.11961 IS - 4 JO - Oncol Lett KW - glutathione S‑transferase Mu The Cancer Genome Atlas gastric cancer prognosis biomarker PY - 2020 SN - 1792-1074 1792-1082 SP - 100 ST - Identification and verification of the prognostic value of the glutathione S‑transferase Mu genes in gastric cancer T2 - Oncology Letters TI - Identification and verification of the prognostic value of the glutathione S‑transferase Mu genes in gastric cancer UR - https://doi.org/10.3892/ol.2020.11961 VL - 20 ER -