TY - JOUR AB - Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. SAR1 gene homolog B (SAR1B) is a GTPase that has been reported to have a central role in the regulation of lipid homeostasis and is associated with numerous diseases. However, its role in cancer, particularly in CRC, remains unclear. The present study revealed that SAR1B was overexpressed in CRC samples and this was associated with shorter overall survival time in patients with CRC. Colony formation, cell proliferation and flow cytometry assays were conducted to evaluate the functions of SAR1B in CRC. It was reported that SAR1B may be associated with tumorigenesis of CRC. Knockdown of SAR1B suppressed cell proliferation and induced significant apoptosis of RKO cells. Furthermore, microarray analysis was performed to identify the potential targets of SAR1B in CRC. Bioinformatics analysis revealed that SAR1B was significantly involved in regulating ‘TGF‑β signaling’, ‘paxillin signaling’, ‘cell cycle regulation by BTG family proteins’ and ‘IGF‑1 signaling’. These results suggested that SAR1B may be considered a potential prognostic biomarker and therapeutic target for CRC. AD - Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang 318000, P.R. China AU - Lu,Yong AU - Zhou,Shen-Kang AU - Chen,Rui AU - Jiang,Liang-Xian AU - Yang,Lei-Lei AU - Bi,Tie-Nan AU - Lu,Yong AU - Zhou,Shen-Kang AU - Chen,Rui AU - Jiang,Liang-Xian AU - Yang,Lei-Lei AU - Bi,Tie-Nan DA - 2020/11/01 DO - 10.3892/ol.2020.12048 IS - 5 JO - Oncol Lett KW - colorectal cancer SAR1 gene homolog B cell growth cell apoptosis PY - 2020 SN - 1792-1074 1792-1082 SP - 186 ST - Knockdown of SAR1B suppresses proliferation and induces apoptosis of RKO colorectal cancer cells T2 - Oncology Letters TI - Knockdown of SAR1B suppresses proliferation and induces apoptosis of RKO colorectal cancer cells UR - https://doi.org/10.3892/ol.2020.12048 VL - 20 ER -