TY - JOUR AB - Primary effusion lymphoma (PEL) is a B‑cell non‑Hodgkin's lymphoma that is usually characterized by lymphomatous effusions in the body cavity without any detectable tumor masses. According to the World Health Organization (WHO) schema for tumor classification, PEL is defined by the presence of human herpesvirus 8 (HHV8) in malignant lymphoid cells. However, a subset of effusion‑based B‑cell lymphoma is not HHV8‑positive and exhibits different clinicopathological characteristics. The 2017 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues does not list HHV8‑negative effusion‑based lymphoma, which remains an underappreciated B‑cell lymphoma, as an individual entity. The present study reports a case of this rare type of lymphoma with indolent clinical behavior in a 75‑year‑old male patient receiving only symptomatic treatment. Additionally, a review of similar cases reported in the English literature is presented. AD - Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea Division of Hematology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea AU - Kim,Moonsik AU - An,Jiyeon AU - Yoon,Sun,Och AU - Yong,Seung,Hyun AU - Kim,Jin ,Seok AU - Yang,Woo,Ick AU - Leem,Ah,Young DA - 2020/12/01 DO - 10.3892/ol.2020.12206 IS - 6 JO - Oncol Lett KW - human herpesvirus 8‑negative effusion‑based lymphoma primary effusion lymphoma indolent non‑Hodgkin's lymphoma PY - 2020 SN - 1792-1074 1792-1082 SP - 343 ST - Human herpesvirus 8‑negative effusion‑based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review T2 - Oncology Letters TI - Human herpesvirus 8‑negative effusion‑based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review UR - https://doi.org/10.3892/ol.2020.12206 VL - 20 ER -