TY - JOUR AB - Long non‑coding RNAs (lncRNAs) play an important role in gene regulation. Several lncRNAs have been demonstrated to be associated with the diagnosis and prognosis of non‑small cell lung cancer (NSCLC). The present study aimed to investigate the role of lncRNA long intragenic non‑protein‑coding RNA p53‑induced transcript (LINC‑PINT) in NSCLC to identify a novel non‑invasive biomarker for the diagnosis and prognosis of patients with NSCLC. Reverse transcription‑quantitative PCR analysis was performed to detect LINC‑PINT expression in the tissue and serum samples of patients with NSCLC. The diagnostic and prognostic values of LINC‑PINT were assessed via the receiver operating characteristic curve, and Kaplan‑Meier and Cox regression analyses, respectively. The results demonstrated that LINC‑PINT expression was significantly downregulated in NSCLC serum samples and tissues. In addition, serum LINC‑PINT exhibited diagnostic value in patients with NSCLC, and may be used to predict prognosis. Furthermore, aberrant LINC‑PINT expression in tumor tissues was significantly associated with lymph node metastasis, tumor size, differentiation and TNM stage. Taken together, the results of the present study suggest that lncRNA LINC‑PINT may be an independent diagnostic and prognostic biomarker in NSCLC. AD - Department of Clinical Laboratory, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China Outpatient Dressing Room, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China Department of Pathology, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China Department of Blood Transfusion, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China AU - Zhang,Chunjie AU - Gong,Cuixue AU - Li,Jianzhao AU - Tang,Jiaying DA - 2021/03/01 DO - 10.3892/ol.2021.12471 IS - 3 JO - Oncol Lett KW - non‑small cell lung cancer long intragenic non‑protein‑coding RNA p53‑induced transcript diagnostic prognostic PY - 2021 SN - 1792-1074 1792-1082 SP - 210 ST - Downregulation of long non‑coding RNA LINC‑PINT serves as a diagnostic and prognostic biomarker in patients with non‑small cell lung cancer T2 - Oncology Letters TI - Downregulation of long non‑coding RNA LINC‑PINT serves as a diagnostic and prognostic biomarker in patients with non‑small cell lung cancer UR - https://doi.org/10.3892/ol.2021.12471 VL - 21 ER -