TY - JOUR AB - BRCA1 is a tumor suppressor that has been found to be involved DNA synthesis during cell replication. In a recent study, the single nucleotide polymorphism (SNP), rs799917, in BRCA1 was found to be associated with the development and progression of various types of tumor. In the present study, the association between rs799917 and susceptibility to lung cancer was evaluated in a Han Chinese population in the Liaoning Province of China. The BRCA1 rs799917 genotypes (C/C, C/T and T/T) were analyzed using TaqMan quantitative PCR in 682 patients with lung cancer and 694 healthy controls, and the results were analyzed using a Student's t‑test, a χ2 test and logistic regression analysis. Individuals carrying the C/T or T/T genotype had a lower risk of lung cancer compared with those carrying the C/C genotype [odds ratio (OR), 0.741; P=0.021; and OR, 0.610; P=0.011, respectively). The C/T + T/T genotype group had an even lower risk (OR, 0.709; P=0.005) compared with that in the C/C genotype group. In the stratified analyses of non‑smokers, individuals with the C/T or T/T genotype had a lower risk of developing lung cancer compared with that in those carrying the C/C genotype (OR, 0.681; P=0.013; and OR, 0.569; P=0.021, respectively). The stratified analyses of the BRCA1 rs799917 polymorphism based on pathological type, chemotherapy and radiotherapy, showed that in the squamous cell carcinoma, non‑chemotherapy and non‑radiotherapy subgroups, individuals with the T/T genotype had a lower risk of lung cancer compared with that in those carrying the C/C genotype (OR, 0.454; P=0.007; OR, 0.485; P=0.002; and OR, 0.599; P=0.020, respectively). In conclusion, the T allele of the rs799917 SNP in BRCA1 was associated with a lower risk of lung cancer in the ethnic Han Chinese population in Liaoning Province and may represent a protective factor against lung cancer. AD - Department of Radiation Oncology, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Radiation Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning 110042, P.R. China Department of Epidemiology, China Medical University, Shenyang, Liaoning 110001, P.R. China AU - Liu,Dan AU - Gao,Ya AU - Li,Lingling AU - Chen,He AU - Bai,Lu AU - Qu,Yanli AU - Zhou,Baosen AU - Yan,Ying AU - Zhao,Yuxia DA - 2021/05/01 DO - 10.3892/ol.2021.12685 IS - 5 JO - Oncol Lett KW - genes BRCA1 lung cancer single nucleotide polymorphism PY - 2021 SN - 1792-1074 1792-1082 SP - 424 ST - Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer T2 - Oncology Letters TI - Single nucleotide polymorphisms in breast cancer susceptibility gene 1 are associated with susceptibility to lung cancer UR - https://doi.org/10.3892/ol.2021.12685 VL - 21 ER -