TY - JOUR AB - Aryl hydrocarbon receptor (AHR) is a ligand‑­activated transcription factor, whose canonical pathway mainly regulates the genes involved in xenobiotic metabolism. However, it can also regulate several responses in a non‑­canonical manner, such as proliferation, differentiation, cell death and cell adhesion. AhR plays an important role in central nervous system tumors, as it can regulate several cellular responses via different pathways. The polymorphisms of the AHR gene have been associated with the development of gliomas. In addition, the metabolism of tumor cells promotes tumor growth, particularly in tryptophan synthesis, where some metabolites, such as kynurenine, can activate the AhR pathway, triggering cell proliferation in astrocytomas, medulloblastomas and glioblastomas. Furthermore, as part of the changes in neuroblastomas, AHR is able to downregulate the expression of proto‑oncogene c‑Myc, induce differentiation in tumor cells, and cause cell cycle arrest and apoptosis. Collectively, these data suggested that the modulation of the AhR pathway may downregulate tumor growth, providing a novel strategy for applications for the treatment of certain tumors through the control of the AhR pathway. AD - Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Mexico City 06720, México AU - Zaragoza‑Ojeda,Montserrat AU - Apatiga‑Vega,Elisa AU - Arenas‑Huertero,Francisco DA - 2021/06/01 DO - 10.3892/ol.2021.12721 IS - 6 JO - Oncol Lett KW - brain tumors astrocytoma medulloblastoma neuroblastoma aryl hydrocarbon receptor PY - 2021 SN - 1792-1074 1792-1082 SP - 460 ST - Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review) T2 - Oncology Letters TI - Role of aryl hydrocarbon receptor in central nervous system tumors: Biological and therapeutic implications (Review) UR - https://doi.org/10.3892/ol.2021.12721 VL - 21 ER -