TY - JOUR AB - Tumor development and progression are closely associated with various microRNAs (miRNAs/miRs). We have previously shown that Newcastle disease virus (NDV) strain 7793 induces oncolysis in lung cancer. However, how NDV exerts its oncolytic effect on lung cancer remains to be investigated. The present study assessed the role of miR‑204 in the NDV‑induced oncolysis of lung cancer A549 cells by oncolysis induction in vitro. miR‑204 was significantly upregulated in NDV‑treated A549 cells. Overexpression or inhibition of miR‑204 was significantly associated with NDV‑induced oncolysis in A549 cells. Caspase‑3 and Bax, major regulators of the apoptosis pathway, were regulated by miR‑204, and the association between caspase‑3‑related apoptosis and miR‑204 was identified in NDV‑mediated oncolysis. These data demonstrated that miR‑204 as a tumor suppressor played a role in NDV‑induced oncolysis in lung cancer cells. The present study demonstrates the potential of strategies using miRs to improve oncolytic NDV potency, and highlights miR‑204 as a tumor suppressor in NDV‑induced oncolysis of lung cancer cells. AD - Department of Microbiology, School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Department of Clinical Laboratory, Tianjin Children's Hospital, Tianjin 300000, P.R. China AU - Liang,Ying AU - Tian,Wen-Yu AU - Huang,Juan-Juan AU - Gao,Ling-Xi AU - Fan,Xiao-Hui DA - 2021/06/01 DO - 10.3892/ol.2021.12743 IS - 6 JO - Oncol Lett KW - Newcastle disease virus A549 microRNA lung cancer oncolysis PY - 2021 SN - 1792-1074 1792-1082 SP - 482 ST - MicroRNA‑204 plays a role as a tumor suppressor in Newcastle disease virus‑induced oncolysis in lung cancer A549 cells T2 - Oncology Letters TI - MicroRNA‑204 plays a role as a tumor suppressor in Newcastle disease virus‑induced oncolysis in lung cancer A549 cells UR - https://doi.org/10.3892/ol.2021.12743 VL - 21 ER -