TY - JOUR
AB - Valuable diagnostic and prognostic biomarkers are urgently needed for colorectal cancer (CRC), which is one of the leading causes of mortality worldwide. Previous studies have reported altered expression of a mucin‑like protein Fc fragment of IgG binding protein (FCGBP) in various types of cancer, but its potential diagnostic, prognostic and immunological roles in CRC remain to be determined. Therefore, the aim of current study was to investigate the potential roles of FCGBP in CRC. The present study investigated FCGBP mutations and changes in its expression levels using a combination of microarray and public dataset analyses, as well as immunohistochemistry. The results demonstrated a 10.5% mutation frequency in the FCGBP coding sequence in CRC tissues, and identified decreased FCGBP mRNA or protein expression levels in colorectal adenoma and CRC (compared with those in normal colorectal tissues from healthy control subjects), including pathologically advanced CRC (stage Ⅲ+Ⅳ vs. I+II). Survival analysis using the GEPIA and Kaplan‑Meier Plotter databases revealed that low FCGBP expression levels were associated with short overall, disease‑free, relapse‑free and event‑free survival times in patients with CRC. Notably, analysis using the online Tumor IMmune Estimation Resource database revealed a positive correlation between FCGBP expression levels and the extent of infiltrating immune cells, such as B cells and dendritic cells. Consistently, the expression levels of most markers (51/57) for various types of immune cells were significantly correlated with FCGBP expression levels in CRC tissues. These findings suggested that FCGBP may serve as a diagnostic and prognostic biomarker, and that FCGBP may be associated with immune infiltration in CRC.
AD - Biomedical Research Center of South China, Fujian Normal University, Fuzhou, Fujian 350117, P.R. China
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, P.R. China
AU - Zhuang,Qunchuan
AU - Shen,Aling
AU - Liu,Liya
AU - Wu,Meizhu
AU - Shen,Zhiqing
AU - Liu,Huixin
AU - Cheng,Ying
AU - Lin,Xiaoying
AU - Wu,Xiangyan
AU - Lin,Wei
AU - Li,Jiapeng
AU - Han,Yuying
AU - Chen,Xiaoping
AU - Chen,Qi
AU - Peng,Jun
DA - 2021/07/01
DO - 10.3892/ol.2021.12787
IS - 1
JO - Oncol Lett
KW - colorectal cancer
Fc fragment of IgG binding protein
survival
immune cell infiltration
biomarker
PY - 2021
SN - 1792-1074
1792-1082
SP - 526
ST - Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer
T2 - Oncology Letters
TI - Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer
UR - https://doi.org/10.3892/ol.2021.12787
VL - 22
ER -