TY - JOUR
AB - Required for meiotic nuclear division 5 homolog A (RMND5A) functions as an E3 ubiquitin ligase. To date, few studies have investigated the role of RMND5A in cancer. In the present study, the expression levels of RMND5A in multiple types of cancer were analyzed using the Gene Expression Profiling Interactive Analysis platform. The results revealed that RMND5A was highly expressed and associated with overall survival in patients with pancreatic adenocarcinoma (PAAD). A wound‑healing assay revealed that RMND5A overexpression significantly increased cell migration in the PAAD cell lines AsPC‑1 and PANC‑1. In silico analysis predicted that RMND5A was a potential target of microRNA(miR)‑590‑5p. Further in vitro experiments demonstrated that overexpression of miR‑590‑5p downregulated the expression levels of RMND5A and decreased the migratory ability of the AsPC‑1 and PANC‑1 cell lines. In addition, overexpression of miR‑590‑5p attenuated the promoting effects of RMND5A on the migration of AsPC‑1 and PANC‑1 cells. The results of the present study may further elucidate the mechanisms underlying PAAD progression and provide novel targets for the treatment of PAAD.
AD - The Center for Heart Development, State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China
Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510100, P.R. China
AU - Chen,Sixing
AU - Chen,Yu
AU - Wen,Yao
AU - Cai,Wanwan
AU - Zhu,Ping
AU - Yuan,Wuzhou
AU - Li,Yongqing
AU - Fan,Xiongwei
AU - Wan,Yongqi
AU - Li,Fang
AU - Zhuang,Jian
AU - Jiang,Zhigang
AU - Wu,Xiushan
AU - Wang,Yuequn
DA - 2021/07/01
DO - 10.3892/ol.2021.12793
IS - 1
JO - Oncol Lett
KW - microRNA‑590‑5p
cell migration
pancreatic cancer
required for meiotic nuclear division 5 homolog A
prognosis
PY - 2021
SN - 1792-1074
1792-1082
SP - 532
ST - miR‑590‑5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines
T2 - Oncology Letters
TI - miR‑590‑5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines
UR - https://doi.org/10.3892/ol.2021.12793
VL - 22
ER -