TY - JOUR AB - C1q tumor necrosis factor‑related proteins (CTRPs), which are members of the adipokine superfamily, have gained significant interest in the recent years. CTRPs are homologs of adiponectin with numerous functions and are closely associated with metabolic diseases, such as abnormal glucose and lipid metabolism and diabetes. Previous studies have demonstrated that CTRPs are highly involved in the regulation of numerous physiological and pathological processes, including glycolipid metabolism, protein kinase pathways, cell proliferation, cell apoptosis and inflammation. CTRPs also play important roles in the development and progression of numerous types of tumor, including liver, colon and lung cancers. This observation can be attributed to the fact that diabetes, obesity and insulin resistance are independent risk factors for tumorigenesis. Numerous CTRPs, including CTRP3, CTRP4, CTRP6 and CTRP8, have been reported to be associated with tumor progression by activating multiple signal pathways. CTRPs could therefore be considered as diagnostic markers and therapeutic targets in some cancers. However, the underlying mechanisms of CTRPs in tumorigenesis remain unknown. The present review aimed to determine the roles and underlying mechanisms of CTRPs in tumorigenesis, which may help the development of novel cancer treatments in the future. AD - Department of Endocrinology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China Department of Respiratory, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China Department of Dermatology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei 067000, P.R. China AU - Kong,Mowei AU - Gao,Yu AU - Guo,Xiang AU - Xie,Yuyu AU - Yu,Yamei DA - 2021/10/01 DO - 10.3892/ol.2021.12984 IS - 4 JO - Oncol Lett KW - tumor C1q tumor necrosis factor‑related protein biomarker metabolism PY - 2021 SN - 1792-1074 1792-1082 SP - 723 ST - Role of the CTRP family in tumor development and progression (Review) T2 - Oncology Letters TI - Role of the CTRP family in tumor development and progression (Review) UR - https://doi.org/10.3892/ol.2021.12984 VL - 22 ER -