TY - JOUR AB - Esophageal cancer is one of the most common malignancies and leading cause of cancer‑associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified as an adipose tissue‑secretory factor, has been associated with obesity‑related diseases, including certain types of cancer. Thus, the present study aimed to investigate the expression levels of resistin in tissue and serum specimens from patients with esophageal squamous cell carcinoma (ESCC) to determine the potential biological effects of resistin on ESCC cells. The results demonstrated that both tissue and serum resistin levels were significantly lower in patients with ESCC compared with healthy controls. In addition, resistin expression was positively associated with the body mass index of patients with ESCC. In vitro studies revealed that resistin inhibited the migratory ability of ESCC cells, while having no effect on ESCC cell proliferation. Taken together, these results suggest that resistin may have the potential to be developed into a clinical marker for ESCC. However, further studies are required to investigate resistin receptor expression and determine the potential involvement of resistin‑associated biological pathways, which may provide insight for future development of targeted therapies for resistin‑mediated ESCC. AD - Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C. Department of Oral Hygiene, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C. Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan, R.O.C. School of Dentistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C. Department of Dentistry, China Medical University Hospital, Taichung 406, Taiwan, R.O.C. Department of Dermatology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan, R.O.C. AU - Hung,Amos,C. AU - Wang,Yen-Yun AU - Lee,Kun-Tsung AU - Chiang,Hung-Hsing AU - Chen,Yuk-Kwan AU - Du,Je-Kang AU - Chen,Chun-Ming AU - Chen,Michael,Yuanchien AU - Chen,Kwei-Jing AU - Hu,Stephen,Chu-Sung AU - Yuan,Shyng-Shiou,F. DA - 2021/11/01 DO - 10.3892/ol.2021.13035 IS - 5 JO - Oncol Lett KW - adipocytokine resistin body mass index esophageal cancer adenylyl cyclase‑associated protein 1 toll‑like receptor 4 PY - 2021 SN - 1792-1074 1792-1082 SP - 774 ST - Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma T2 - Oncology Letters TI - Reduced tissue and serum resistin expression as a clinical marker for esophageal squamous cell carcinoma UR - https://doi.org/10.3892/ol.2021.13035 VL - 22 ER -