TY - JOUR AB - Colorectal cancer (CRC) is one of the most common types of malignancy worldwide and has a poor prognosis. Non‑SMC condensing I complex subunit G (NCAPG) has been reported to be upregulated in numerous types of malignant tumor. However, to the best of our knowledge, its clinicopathological and biological significance in CRC remain to be elucidated. The results of the present study revealed that NCAPG expression levels were upregulated in human CRC tissues and cell lines. The upregulated expression of NCAPG was positively associated with patient clinicopathological characteristics, such as differentiation and tumor size, and independently associated with poor survival. Consistent with the clinical observations, NCAPG was discovered to promote the proliferation and inhibit the apoptosis of CRC cells. Moreover, NCAPG‑knockdown inhibited CRC cell proliferation by regulating the PI3K/AKT signaling pathway. Furthermore, NCAPG was identified as a potential target of microRNA (miR)‑23b‑3p, which was subsequently demonstrated to negatively regulate NCAPG expression. In conclusion, the findings of the current study indicated that the miR‑23b‑3p/NCAPG/PI3K/AKT signaling axis may play an important role in CRC carcinogenesis, and the status of the molecule may represent a promising prognostic marker for the disease. AD - The Second Department of Gastrointestinal Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China Nanchong Inspection Institute for Food and Drugs, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China Anorectal Department of Integrated Traditional Chinese and Western Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China AU - Li,Peidong AU - Wen,Jing AU - Ren,Xiru AU - Zhou,Yu AU - Xue,Yuan AU - Yan,Zaihua AU - Li,Shengjie AU - Tian,Hongpeng AU - Tang,Xue-Gui AU - Zhang,Guang-Jun DA - 2021/12/01 DO - 10.3892/ol.2021.13073 IS - 6 JO - Oncol Lett KW - colorectal cancer non‑SMC condensing I complex subunit G microRNA‑23b‑3p proliferation apoptosis PI3K/AKT pathway PY - 2021 SN - 1792-1074 1792-1082 SP - 812 ST - MicroRNA‑23b‑3p targets non‑SMC condensing I complex subunit G to promote proliferation and inhibit apoptosis of colorectal cancer cells via regulation of the PI3K/AKT signaling pathway T2 - Oncology Letters TI - MicroRNA‑23b‑3p targets non‑SMC condensing I complex subunit G to promote proliferation and inhibit apoptosis of colorectal cancer cells via regulation of the PI3K/AKT signaling pathway UR - https://doi.org/10.3892/ol.2021.13073 VL - 22 ER -