TY - JOUR AB - Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta‑analysis was used to examine the associations between Ki67 levels and GIST recurrence. Studies reporting GIST and Ki67 were found by searching Cochrane Library, PubMed and Embase until October 14, 2021. The Newcastle‑Ottawa Scale (NOS) was used to verify the quality of the evidence. Totally, 1682 patient cases were included. The odds ratio (OR) estimates and 95% confidence interval (CI) for each publication were determined by a fixed‑effects (Mantel‑Haenszel) model. A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis. The average score of quality evaluation was 6.4 points according to NOS. It was found that Ki67 levels were significantly higher in the NIH L group compared with the NIH VL group (OR: 0.51; 95% CI: 0.26‑0.99; P=0.04; P heterogeneity=0.44). There was also greater Ki67 overexpression in the NIH I group compared with the NIH L group (OR: 0.45, 95% CI: 0.31‑0.65; P<0.0001; P heterogeneity=0.32), while Ki67 levels were greater in the NIH H group than in the NIH I group (OR: 0.20; 95% CI: 0.15‑0.28; P<0.00001; P heterogeneity=0.56). In conclusion, Ki67 overexpression may be a useful marker of the risk of recurrent GIST transformation. AD - Department of General Surgery, Chongqing Western Hospital, Chongqing 400051, P.R. China Department of Radiology, Army Medical Center of PLA, Chongqing 400042, P.R. China AU - Li,Ji AU - Wang,An-Ran AU - Chen,Xiao-Dong AU - Pan,Hong AU - Li,Shi-Qiang DA - 2022/06/01 DO - 10.3892/ol.2022.13309 IS - 6 JO - Oncol Lett KW - gastrointestinal stromal tumors Ki‑67 meta‑analysis malignant risk PY - 2022 SN - 1792-1074 1792-1082 SP - 189 ST - Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis T2 - Oncology Letters TI - Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis UR - https://doi.org/10.3892/ol.2022.13309 VL - 23 ER -