TY - JOUR AB - Rectal adenocarcinoma (READ) constitutes one‑third of newly diagnosed colorectal cancer cases. Surgery, chemotherapy and concurrent chemoradiotherapy are the main treatments to improve patient outcomes for READ. However, patients with READ receiving these treatments eventually relapse, leading to a poor survival outcome. The present study collected surgical specimens from patients with READ and determined that cytoplasmic cell division cycle 27 (CDC27) expression was associated with the risk of lymph node metastasis and distant metastasis. Nuclear CDC27 expression was negatively associated with 5‑year disease‑free survival (DFS) and 5‑year overall survival (OS) rates. Multivariate Cox proportional regression analysis showed that nuclear CDC27 was an independent prognostic factor in the patients with READ, especially in those treated with adjuvant chemotherapy. High nuclear CDC27 expression was significantly associated with poorer 5‑year DFS (HR, 2.106; 95% CI, 1.275‑3.570; P=0.003) and 5‑year OS (HR, 2.369; 95% CI, 1.270‑4.6810; P=0.005) rates. The data indicated that cytoplasmic CDC27 expression could affect tumor progression and that it plays an important role in metastasis. Nuclear CDC27 expression was markedly associated with poorer survival outcomes and was an independent prognostic factor in patients with postoperative adjuvant chemotherapy‑treated READ. Thus, CDC27 expression serves as a potential prognostic marker for rectal tumor progression and chemotherapy treatment. AD - Department of Hematology and Oncology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40402, Taiwan, R.O.C. Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan, R.O.C. Department of Colorectal Surgery, Hsinchu China Medical University Hospital, Hsinchu 30272, Taiwan, R.O.C. Department of Pathology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C. Laboratory of Precision Medicine, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C. Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan, R.O.C. AU - Chang,Chia-Lin AU - Huang,Kevin,Chih-Yang AU - Chen,Tsung-Wei AU - Chen,William,Tzu-Liang AU - Huang,Hsuan-Hua AU - Liu,Ya-Ling AU - Kuo,Chia-Hui AU - Chao,K.S.,Clifford AU - Ke,Tao-Wei AU - Chiang,Shu-Fen AU - Chang,Chia-Lin AU - Huang,Kevin,Chih-Yang AU - Chen,Tsung-Wei AU - Chen,William,Tzu-Liang AU - Huang,Hsuan-Hua AU - Liu,Ya-Ling AU - Kuo,Chia-Hui AU - Chao,K.S.,Clifford AU - Ke,Tao-Wei AU - Chiang,Shu-Fen DA - 2022/07/01 DO - 10.3892/ol.2022.13358 IS - 1 JO - Oncol Lett KW - CDC27 nuclear cytoplasmic chemotherapy efficacy metastasis PY - 2022 SN - 1792-1074 1792-1082 SP - 238 ST - Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy T2 - Oncology Letters TI - Prognostic and clinical significance of subcellular CDC27 for patients with rectal adenocarcinoma treated with adjuvant chemotherapy UR - https://doi.org/10.3892/ol.2022.13358 VL - 24 ER -