TY - JOUR
AB - Common variants of genes involved in DNA damage correction [tumor protein p53 (TP53), murine double 2 homolog oncoprotein (MDM2) and ataxia‑telengiectasia mutated (ATM)] may serve a role in cancer predisposition. The purpose of the present study was to investigate the association of five variants in these genes with breast cancer risk and clinicopathological traits in a cohort of 261 women from northern Sardinia. Polymorphic variants in TP53 (rs17878362, rs1042522 and rs1625895), MDM2 (rs2279744) and ATM (rs1799757) were determined by PCR and TaqMan single nucleotide polymorphism assay in patients with breast cancer (n=136) and healthy controls (n=125). Association with clinicopathological (e.g., age at diagnosis, lymph node involvement, clinical stage) and lifestyle factors (e.g., smoking status, alcohol intake, contraceptive use) was also evaluated. TP53 rs17878362 and rs1625895 polymorphisms were associated with decreased risk of BC diagnosis in patients older than 50 years (codominant and recessive models) and post‑menopause (recessive model). Furthermore, there was a significant association between lymph node status (positive vs. negative) and ATM rs1799757‑delT in dominant and additive models and between MDM2 rs2279744‑allele and use of oral contraceptives. This analysis suggested that TP53 rs17878362 and rs1625895 may affect age of onset of breast cancer and ATM rs1799757 and MDM2 rs2279744 may be associated with lymph node status and prolonged use of oral contraceptives, respectively.
AD - Department of Biomedical Sciences, Surgery and Pharmacy, University of Sassari, Sassari, I-07100 Sardinia, Italy
Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, I-07100 Sardinia, Italy
Institute for Genetic and Biomedical Research, National Research Council, Monserrato, Cagliari, I-09121 Sardinia, Italy
Division of Medical Oncology, Azienda Ospedaliera Universitaria, Sassari, I-07100 Sardinia, Italy
Unit of Occupational Medicine, Azienda Ospedaliera Universitaria, Sassari, I-07100 Sardinia, Italy
Lega Italiana per la Lotta contro i Tumori, Sassari, I-07100 Sardinia, Italy
AU - Floris,Matteo
AU - Pira,Giovanna
AU - Castiglia,Paolo
AU - Idda,Maria,Laura
AU - Steri,Maristella
AU - De Miglio,Maria,Rosaria
AU - Piana,Andrea
AU - Cossu,Andrea
AU - Azara,Antonio
AU - Arru,Caterina
AU - Deiana,Giovanna
AU - Putzu,Carlo
AU - Sanna,Valeria
AU - Carru,Ciriaco
AU - Serra,Antonello
AU - Bisail,Marco
AU - Muroni,Maria,Rosaria
AU - Floris,Matteo
AU - Pira,Giovanna
AU - Castiglia,Paolo
AU - Idda,Maria,Laura
AU - Steri,Maristella
AU - De Miglio,Maria,Rosaria
AU - Piana,Andrea
AU - Cossu,Andrea
AU - Azara,Antonio
AU - Arru,Caterina
AU - Deiana,Giovanna
AU - Putzu,Carlo
AU - Sanna,Valeria
AU - Carru,Ciriaco
AU - Serra,Antonello
AU - Bisail,Marco
AU - Muroni,Maria,Rosaria
DA - 2022/10/01
DO - 10.3892/ol.2022.13451
IS - 4
JO - Oncol Lett
KW - tumor protein p53
murine double 2 homolog oncoprotein
ataxia‑telengiectasia mutated
breast cancer
single nucleotide polymorphism
PY - 2022
SN - 1792-1074
1792-1082
SP - 331
ST - Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women
T2 - Oncology Letters
TI - Impact on breast cancer susceptibility and clinicopathological traits of common genetic polymorphisms in TP53, MDM2 and ATM genes in Sardinian women
UR - https://doi.org/10.3892/ol.2022.13451
VL - 24
ER -