TY - JOUR AB - The objective of the present systematic review was the determination of methodologies preferable for treating phyllodes tumors (PTs) of the breast and whether the malignancy of the tumor is of significance to the selected treatment. In addition, to investigate if local recurrence (LR) within patients is different based on the therapeutic approach followed by the physician. All studies were gathered by utilization of the biggest online medical databases in the world including PubMed, Cochrane, Embase, Web of Science and Google Scholar. Due to the specificity of the study, the resultant set of studies included in the present analysis was not large. All included studies had to refer to patients diagnosed with PTs of the breast, include the malignancy of the tumor and the preferred treatment. Moreover, they included a reference to LR post‑treatment, even if there wasn't any. The age range of patients was 20‑55 years old and follow‑ups should have been performed. As a result, from the initial 484 studies gathered and after proper and thorough evaluation, only 10 were of significance. The studies appeared heterogeneous in terms of population, topology, treatment methodology, additional therapeutic approaches, LR rate, age and follow‑up periods. Overall, excisions were used for non‑malignant tumors while mastectomy was preferable for tumors with malignancy. Radiotherapy was used both as an additional treatment for tumors and LR. Also, it was revealed that LR varied based on the malignancy and treatment methodology. AD - Breast Unit, Athens Medical Center, Psychiko Clinic, 11525 Athens, Greece Third Department of Obstetrics and Gynecology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece Second Department of Pathology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece First Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece AU - Boutas,Ioannis AU - Kontogeorgi,Adamandia AU - Dimas,Dionysios AU - Koufopoulos,Nektarios AU - Genitsaridi,Sofia-Maria AU - Sitara,Kyparissia AU - Kalantaridou,Sophia AU - Dimitrakakis,Constantine DA - 2022/10/01 DO - 10.3892/ol.2022.13473 IS - 4 JO - Oncol Lett KW - breast conserving surgery local excision local recurrence phyllodes tumor phyllodes tumor of the breast radiotherapy rare occurrence systematic review wide excision PY - 2022 SN - 1792-1074 1792-1082 SP - 353 ST - Local recurrence for phyllodes tumours of the breast: Systematic review and meta‑analysis T2 - Oncology Letters TI - Local recurrence for phyllodes tumours of the breast: Systematic review and meta‑analysis UR - https://doi.org/10.3892/ol.2022.13473 VL - 24 ER -