TY - JOUR AB - Salvage surgery for recurrent oral squamous cell carcinoma (OSCC) often leads to a poor quality of life (QOL). The present study described three cases that resulted in favorable locoregional control with cetuximab in combination with radiotherapy (Cmab + RT). Case 1 had regional recurrence of OSCC at the lower right mastoid area 4 months after primary surgery. Case 2 had regional recurrence of OSCC at the parotid area 7 months after primary surgery. Case 3 had local recurrence of OSCC at the masticatory muscle and Rouviere's lymph nodes 1 year and 3 months after primary surgery. In all cases, Cmab + RT was performed, and disease‑free survival was confirmed 4 months, 2 years and 6 months, and 10 months after Cmab + RT, respectively. Immunohistochemically, all resected tumors had no expression of 110‑kDa catalytic subunit of class IA phosphatidylinositol 3‑kinase (PI3Kp110α). In conclusion, if salvage surgery for recurrent OSCC results in a significantly low QOL, then shifting to chemoradiotherapy may be appropriate as a treatment strategy. In addition, strong evidence indicated that PI3Kp110α expression is associated with Cmab therapy efficacy. AD - Department of Clinical Oral Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8588, Japan AU - Naruse,Tomofumi AU - Furukawa,Kohei AU - Miyoshi,Taro AU - Morishita,Kota AU - Otsuru,Mitsunobu AU - Umeda,Masahiro DA - 2022/12/01 DO - 10.3892/ol.2022.13551 IS - 6 JO - Oncol Lett KW - Cmab RT locoregional recurrence PI3Kp110α salvage surgery PY - 2022 SN - 1792-1074 1792-1082 SP - 431 ST - Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series T2 - Oncology Letters TI - Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series UR - https://doi.org/10.3892/ol.2022.13551 VL - 24 ER -