TY - JOUR AB - This study aimed to evaluate the clinical outcomes of patients with T3‑4aN0M0 glottic laryngeal squamous cell carcinoma (LSCC) treated with laryngectomy, and to assess the postoperative radiotherapy (PORT) results in terms of the survival of T3‑T4aN0M0 patients with negative margins. This was a retrospective review of 369 T3‑4aN0M0 glottic LSCC cases. The 5‑year cancer‑specific survival (CSS) and overall survival (OS) rates were 67.5 and 66.7%, respectively. Patients who received total laryngectomy had worse survival [5‑year CSS, 62.5%; disease‑free survival (DFS), 56.2%] than those who underwent partial laryngectomy (5‑year CSS, 79.3%; DFS, 65.4%). More advanced‑stage cancer is a predictor of poor survival. There was no significant difference in CSS or DFS between patients with positive margins following rescue therapy and those with negative margins. Furthermore, no difference in the survival rates was observed between patients with negative margins who received PORT and those who did not (5‑year DFS: 59.1 vs. 63.8%, P=0.057 and CSS: 62.5 vs. 69.5%, P=0.074). For T3‑4aN0M0 glottic LSCC patients, surgical treatment remained a good option, as it can achieve satisfactory oncological outcomes. However, PORT did not increase survival in surgically managed pT3‑4aN0M0 LSCC patients with negative margins. AD - Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China AU - Zhou,Jian AU - Heng,Yu AU - Yang,Yue AU - Zhu,Xiaoke AU - Zhou,Liang AU - Gong,Hongli AU - Xu,Chengzhi AU - Tao,Lei DA - 2022/12/01 DO - 10.3892/ol.2022.13554 IS - 6 JO - Oncol Lett KW - laryngeal squamous cell carcinoma T3‑4aN0M0 survival outcomes surgery postoperative radiotherapy PY - 2022 SN - 1792-1074 1792-1082 SP - 434 ST - Survival outcomes in patients with T3‑4aN0M0 glottic laryngeal squamous cell carcinoma and evaluation of postoperative radiotherapy T2 - Oncology Letters TI - Survival outcomes in patients with T3‑4aN0M0 glottic laryngeal squamous cell carcinoma and evaluation of postoperative radiotherapy UR - https://doi.org/10.3892/ol.2022.13554 VL - 24 ER -