TY - JOUR AB - Although great progress has been made in the early diagnosis and targeted therapy of lung adenocarcinoma (LUAD), the survival of patients with LUAD remains unsatisfactory. There is an urgent requirement for new biomarkers to guide the diagnosis, prognosis and treatment of LUAD. Following an initial bioinformatics screen, the present study focused on cyclin B1 (CCNB1) in LUAD. A total of 94 patients with LUAD from a single hospital were included in the study. CCNB1 protein expression was detected and scored in 94 LUAD samples and 30 normal tissue samples by immunohistochemistry. The associations between CCNB1 expression and the clinicopathological features of the patients with LUAD were analyzed. Furthermore, the relationship between prognosis and the CCNB1 expression level was analyzed using Cox regression and survival analyses. Weighted gene co‑expression network analysis and RNA‑sequencing were also applied to identify the potential molecular mechanisms of CCNB1 in LUAD. CCNB1 was highly expressed in patients with LUAD and was associated with poor prognosis. It may affect the expression of CPLX1, PPIF, SRPK2, KRT8, SLC20A1 and CBX2 genes and function via different pathways. CCNB1 has the potential to become a novel prognostic target for LUAD. AD - Department of Cancer Research Laboratory, Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China Department of Oncology, Guihang Guiyang Hospital, Guiyang, Guizhou 550000, P.R. China Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China AU - Li,Yi AU - Leng,Yuanxiu AU - Dong,Yudi AU - Song,Yongxiang AU - Wu,Qiaoyuan AU - Jiang,Ni AU - Dong,Hui AU - Chen,Fang AU - Luo,Qing AU - Cheng,Chen DA - 2022/12/01 DO - 10.3892/ol.2022.13561 IS - 6 JO - Oncol Lett KW - cyclin B1 lung adenocarcinoma survival RNA‑sequencing weighted gene coexpression‑analysis biomarker PY - 2022 SN - 1792-1074 1792-1082 SP - 441 ST - Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways T2 - Oncology Letters TI - Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways UR - https://doi.org/10.3892/ol.2022.13561 VL - 24 ER -