TY - JOUR AB - The present study aimed to explore the final diagnosis of pulmonary nodules with an initial non‑diagnostic result on electromagnetic navigation bronchoscopy (ENB) biopsy and the predictive factors for a non‑diagnostic result. A total of 198 nodules from 194 patients that were suspected to be malignant tumors were included in the present study. The initial biopsy pathology results were divided into two groups: The diagnostic group and the non‑diagnostic group. The diagnostic group was defined as a successful initial biopsy to obtain a diagnosis, including malignant and benign diagnoses. The non‑diagnostic group was defined as a non‑specific benign diagnosis, normal lung tissue or an unsuccessful biopsy. Among the 198 nodules, 139 (70.2%) were in the diagnostic group and 59 (29.8%) were in the non‑diagnostic group. Predictive factors for a non‑diagnostic biopsy included nodule size ≤1.5 cm [odds ratio (OR), 2.05; 95% confidence interval (CI), 1.03‑4.09], non‑solid nodules (OR, 2.71; 95% CI, 1.33‑5.64) and nodules in the left lung (OR, 2.50; 95% CI, 1.27‑4.92). Of the 59 non‑diagnostic biopsies, 46 were finally confirmed to be malignant by surgery. Notably, non‑diagnostic biopsies with non‑solid nodules (OR, 7.64; 95% CI, 3.11‑18.76) were more likely to be malignant. In conclusion, the predictive factors for a non‑diagnostic biopsy were nodule size ≤1.5 cm and non‑solid nodules. It was not rare for patients to finally be diagnosed with a malignancy in the non‑diagnostic group. Therefore, care should be taken when the results of an ENB are non‑diagnostic to prevent misdiagnosis. AD - Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China Department of Thoracic Surgery, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China AU - Yu,Wenfeng AU - Ma,Honghai AU - Yu,Guocan AU - Xia,Pinghui AU - An,Zhou AU - Yu,Li AU - Lv,Wang AU - Ye,Bo AU - Hu,Jian DA - 2023/04/01 DO - 10.3892/ol.2023.13751 IS - 4 JO - Oncol Lett KW - pulmonary nodule electromagnetic navigation bronchoscopy biopsy lung cancer PY - 2023 SN - 1792-1074 1792-1082 SP - 166 ST - Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses T2 - Oncology Letters TI - Non‑diagnostic electromagnetic navigation bronchoscopy biopsy: Predictive factors and final diagnoses UR - https://doi.org/10.3892/ol.2023.13751 VL - 25 ER -