TY - JOUR
AB - Tumor‑infiltrating lymphocytes (TILs) are important components of the tumor microenvironment (TME). However, the distribution characteristics of TILs and their significance in pancreatic cancer (PC) remain largely unexplored. The levels of TILs, including the total number of T cells, cluster of differentiation (CD)4+ T cells, CD8+ cytotoxic T lymphocytes (CTLs), regulatory T‑cells (Tregs), programmed cell death protein 1+ T cells and programmed cell death ligand 1 (PD‑L1)+ T cells, in the TME of patients with PC were detected using multiple fluorescence immunohistochemistry. The associations between the number of TILs and the clinicopathological characteristics were investigated using χ2 tests. In addition, Kaplan‑Meier survival and Cox regression analyses were used to assess the prognostic value of these TIL types. Compared with paracancerous tissues, in PC tissues, the proportions of total T cells, CD4+ T cells and CD8+ CTLs were markedly decreased, while those of Tregs and PD‑L1+ T cells were significantly increased. The levels of CD4+ T cell and CD8+ CTL infiltrates were inversely associated with tumor differentiation. Higher infiltrates of Tregs and PD‑L1+ T cells were closely associated with advanced N and TNM stages. It is important to note that the infiltrates of total T cells, CD4+ T cells, Tregs and PD‑L1+ T cells in the TME were independent risk factors for the prognosis of PC. PC was characterized by an immunosuppressive TME with a decrease in the number of CD4+ T cells and CD8+ CTLs, and an increase in the number of Tregs and PD‑L1+ T cells. Overall, the number of total T cells, CD4+ T cells, Tregs and PD‑L1+ T cells in the TME was a potential predictive marker for the prognosis of PC.
AD - Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
Department of General Surgery, The Affiliated Hospital of Jiujiang College, Jiujiang, Jiangxi 332001, P.R. China
AU - Sun,Gen
AU - Yang,Zhengjiang
AU - Fang,Kang
AU - Xiong,Yuanpeng
AU - Tu,Shuju
AU - Yi,Siqing
AU - Xiao,Weidong
DA - 2023/06/01
DO - 10.3892/ol.2023.13847
IS - 6
JO - Oncol Lett
KW - pancreatic cancer
tumor immune microenvironment
tumor‑infiltrating lymphocytes
programmed cell death protein 1
programmed cell death ligand 1
PY - 2023
SN - 1792-1074
1792-1082
SP - 261
ST - Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer
T2 - Oncology Letters
TI - Distribution characteristics and clinical significance of infiltrating T cells in the tumor microenvironment of pancreatic cancer
UR - https://doi.org/10.3892/ol.2023.13847
VL - 25
ER -