TY - JOUR AB - This study was conducted to investigate the anti-proliferative activities of medicinal mushroom Ganoderma lucidum (Rei-shi or Mannentake). We have identified an alcohol extract from the spore of Ganoderma lucidum that inhibits the in vitro proliferation of human umbilical vein endothelial cells and MDA-MB231 human breast cancer cells. Further fractionation of the alcohol extract revealed that the ethyl acetate fraction inhibited both cell lines in a dose-dependent manner from 2 to 40 µg/ml. Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities. AD - Department of Medicine, Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA null AU - Lu,Qing-Yi AU - Sartippour,Maryam,R. AU - Brooks,Mai,N. AU - Zhang,Qifeng AU - Hardy,Mary AU - Go,Vay,Liang AU - Li,Frederick,P. AU - Heber,David DA - 2004/09/01 DO - 10.3892/or.12.3.659 EP - 662 IS - 3 JO - Oncol Rep PY - 2004 SN - 1021-335X 1791-2431 SP - 659 ST - Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro T2 - Oncology Reports TI - Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro UR - https://doi.org/10.3892/or.12.3.659 VL - 12 ER -