TY - JOUR AB - The aim of this study was to investigate the role of the mevalonate pathway in the cytostatic/cytotoxic effects of berberine, a natural plant alkaloid that reduces cholesterol concentration. Berberine as well as lovastatin, an inhibitor of the mevalonate pathway, exerted dose-dependent cytostatic/cytotoxic effects against human breast cancer cells (MDA-MB231). Although the mevalonate pathway metabolites (mevalonic acid, farnesyl pyrophosphate, geranylgeranyl pyrophosphate) effectively reversed cytostatic/cytotoxic effects of lovastatin against MDA-MB231 cells, they were not effective in influencing the cytostatic/cytotoxic effects of berberine. The cytostatic/cytotoxic effects of berberine do not seem to result from inhibition of the mevalonate pathway. AD - Department of Immunology, Center of Biostructure Research, The Medical University of Warsaw, Warsaw, Poland null AU - Issat,Tadeusz AU - Jakóbisiak,Marek AU - Golab,Jakub DA - 2006/12/01 DO - 10.3892/or.16.6.1273 EP - 1276 IS - 6 JO - Oncol Rep PY - 2006 SN - 1021-335X 1791-2431 SP - 1273 ST - Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway T2 - Oncology Reports TI - Berberine, a natural cholesterol reducing product, exerts antitumor cytostatic/cytotoxic effects independently from the mevalonate pathway UR - https://doi.org/10.3892/or.16.6.1273 VL - 16 ER -