TY - JOUR AB - Endothelin-1 and its receptors ETAR and ETBR, commonly referred to as the Endothelin-axis, are emerging to play a role in cancer. The Endothelin-axis has been shown to be involved in proliferation, angiogenesis and metastasis in various human tumours. To assess the role of the Endothelin-axis in renal cell carcinoma, we analysed its expression in archival tumour tissue of 183 patients. Representative tumour blocks were selected for constructing a tissue microarray. Paraffin sections were assessed immunohistochemically using monoclonal and polyclonal antibodies for Endothelin-1, ETAR and ETBR. Staining intensities were analysed semiquantitatively and the results were correlated with various histopathologic factors. Overexpression of Endothelin-1, ETAR and ETBR was identified in 12.8%, 84.1% and 93.3% of cases, respectively. No association with pathological tumour stage and histologic grading was found. Papillary renal cell carcinomas expressed highly significantly more Endothelin-1 than clear cell renal cell carcinomas (34.5% vs. 6.7%, p<0.001), while there was no difference between ETAR- and ETBR-expression in these histologic subtypes. However, ETAR tended to be overexpressed in the subgroup of G3-tumours (p=0.044). Studies are underway assessing the role of the Endothelin-axis and its potential use as a molecular target in renal cell carcinoma. AD - Department of Urology, University of Münster, 48149 Münster, Germany. herrmae@ukmuenster.de null AU - Herrmann,Edwin AU - Eltze,Elke AU - Bierer,Stefan AU - Bogemann,Martin AU - Brinkmann,Olaf,Anselm AU - Balnowair,Hoda AU - Hertle,Lothar AU - Wulfing,Christian DA - 2007/02/01 DO - 10.3892/or.17.2.275 EP - 280 IS - 2 JO - Oncol Rep PY - 2007 SN - 1021-335X 1791-2431 SP - 275 ST - Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis T2 - Oncology Reports TI - Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: A tissue microarray analysis UR - https://doi.org/10.3892/or.17.2.275 VL - 17 ER -